Purpose: Bonny light crude oil has been used in folkloric medicine in treating different diseases in combination with Medicinal plants. Cnidoscolus aconitifolius has been reported to possess medicinal properties. This study is aimed at determining experimentally if the acclaimed benefits are true. Methodology: This study investigated the biochemical effect of Bonny light crude oil and Cnidoscolus aconitifolius leaf extract orally administered to albino rats at different concentrations. In this study, albino rats were orally exposed to different concentrations of Bonny light oil (BLCO) and Cnidoscolus aconitifolius leaf extract individually and in combination. Findings: The results after 21days of exposure revealed that BLCO and Cnidoscolus aconitifolius induction at concentrations of 250mg/kgb.wt and 500mg/kgb.wt could induce physiological damage within 21days. This is revealed by the results obtained from the histological analysis of the testes and the detectable heavy metal concentration in the blood samples. Unique Contribution to Theory, Policy and Practice:  As a result, the induction of this leaf extract and BLCO at concentrations of 250mgf/kgb.wt and 500mg/kgb.wt consecutively for 21days may be injurious to health as revealed by the results from the histological analysis. Therefore, it is recommended that the use of this plant leaf extract and BLCO in folkloric medicine at concentrations similar to the ones used in this research should be avoided.

The effect of ethanol extract of the fruiting bodies of Pleurotus ostreatus on serum lipid profile  and atherogenic indices of high sucrose high fat diet streptozotocin (HS-HFD-STZ) induced diabetic rats was determined by standard methods. All the groups were fed high sucrose-high fat diet except the normal group. The Metformin HCl and ethanol extract was given once daily by gavage to the reference and experimental groups respectively at doses of 150mg/Kg b.w., 50mg/Kg   b.w, 150mg/Kg b.w. and 300mg/Kg b.w. respectively while the normal control received saline solution.  The HDL-cholesterol level was higher than the value of the disease group after 6 weeks of administration of extract at 300mg/kg and after 9 weeks administration of extract at 150mg/kg. HDL cholesterol concentration increased by 22.2% after 6 weeks of extract administration at 300mg/kg and by 16.7% and 28.3% respectively after 9 weeks of extract administration at 150mg/kg and 50mg/kg respectively, indicating that the POE extract has the capacity to reduce cardiovascular diseases. At all the doses of extract administered for treatment at 3 weeks, 6 weeks and 9 weeks intervals, there was dose and time dependent lowering of LDL: HDL ratio even below the recommended risk limit of ≤ 2.5 compared to the test control with value above 2.5. After 3 weeks of treatment with extract at administration concentration level of 150mg/kg, atherogenic indices were lowered and extract levels of 150mg/kg and 300mg/kg reduced atherogenic index value after 6 weeks of administration while after 9 weeks of treatment, extract at 150mg/kg concentration reduced atherogenic indices. The atherogenic indices of the diabetic animals under treatment were dose-and time dependently reduced by POE treatment as observed in this study.These results suggest a possible use of the extracts in the management of hyperlipidemic conditions, hypertension and associated complications.