Multiple Myeloma is a blood cancer type B characterized by clonal proliferation of malignant plasma cells. The median age at diagnosis is 70 years. Cases among younger patients are rare, and less than 0,3% patients are younger than 30 years in most series. We report a case of a 25-year-old women. She was suffering from a sacred pain radiating towards the left lower limb and fatigue for three months. A magnetic resonance imaging for dorso-lumbar spine showed an extensive process and multiple osteolytic lesions in second, third and fourth sacred vertebras. She underwent a laparotomy that revealed a dense mass invading the sacrum and the rectum. The histological examination with immunocytochemistry analysis showed a plasmocytoma and the diagnosis of symptomatic multiple myeloma stages III established than she received two courses of chemotherapy. Despite the rarity of multiple myeloma among young patients, this diagnosis should be evoked when clinical, biological and radiological signs are in favor. It appears that there is no difference between younger and elderly patients on the presentation of the disease, although a longer survival reported among young patients.
We are reporting a case of multifocal reversible leucoencephalopathy syndrome induced by chemotherapy based on Folfox-Bevacizumab regimen. A 44-year-old female, with no history of hypertension, received a chemotherapy based on Folfox-Bevacizumab for her metastatic colon cancer (5 FU: 325 mg/m2 d1 by intravenous infusion, Oxaliplatin 80 mg/m2 d1, and Bevacizumab: 7.5 mg/Kg d1). During the fourth cure, she presented delirium, seizures, and visual disturbances. The computed tomography (CT) of the brain showed hypodense lesions of the white matter of frontal, parietal, and occipital lobes, which were bilateral and symmetrical. The clinical table was reversible under symptomatic treatment.
Osteoblastoma is an uncommon benign tumor which commonly affects the vertebrae and the long bones. It occasionally arises in the maxilla. It is important to do differential diagnoses which include osteoid osteoma, giant cell bone tumour, aneurysmal bone cyst and fibrous dysplasia giant cell tumor and osteogenic sarcoma. The current study presents the case of a 14-year-old boy with a tumor in the ethmoid cell and maxillary sinus. Previous literature was reviewed and discussed.
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