AIm: To study the clinicopathologic characteristics of chordomas from a single institution. results:The overall mean age of the patients was 46.72 years. Males outnumbered females. Sacrum was the commonest site involved. Histopathologically, the majority of cases were conventional chordoma with four cases of chondroid variety. There was a single case of dedifferentiated chordoma that presented with bone metastasis. Most patients did well after surgery and radiotherapy. One patient had a local recurrence and one patient with dedifferentiated variant died on follow-up. BulGulAr: Hastaların ortalama yaşı 46,72 yıldı. Erkeklerin sayısı kadınlardan fazlaydı. En sık tutulan bölge sakrumdu. Histopatolojik olarak olguların çoğu konvansiyonel kordomayken kondroid tipte dört olgu vardı. Kemik metastazıyla gelen tek bir dediferansiye kordoma olgusu görüldü. Çoğu hasta cerrahi ve radyoterapiye iyi sonuç verdi. Bir hastada yerel nüks oldu ve dediferansiye varyantın bulunduğu bir hasta da takip sırasında öldü. sOnuÇ: Lokal olarak agresif olmalarına rağmen kordomalar rejeksiyon ve postoperatif radyoterapiyle etkin bir şekilde tedavi edilebilir.

Perivascular spaces surround the small arteries and veins as they enter into the brain parenchyma from the subarachnoid spaces. Also called as Virchow-Robin spaces, these are prominent in the basal ganglia and high convexity white matter of the elderly. Occasionally VR spaces may get massively enlarged and may mimic a cystic mass lesion. The typical CSF-like signal intensity of the cysts and location on MRI, in the absence of a neurological abnormality help in the diagnosis of the giant VR spaces and thus biopsy is avoided. Typically there is no significant adjacent brain abnormality; however FLAIR images may sometimes reveal perilesional white matter hyperintensity, which may be an indication of gliosis due to the mass effect of the lesion. Such a signal alteration should not deter one from making a diagnosis of giant Virchow-Robin spaces when the rest of the imaging findings are typical. We describe a case of a 50-year-old female with incidental giant Virchow-Robin spaces in the right hemispheric subcortical white matter with adjacent white matter hyperintense signal intensity on T2-weighted and FLAIR images.

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Background:Eosinophilic granuloma (EG) of bone refers to a generally benign form of Langerhans cell histiocytosis localized to the bone. Patients may present with a solitary lesion (monostotic) or multiple sites of involvement (polyostotic).Materials and Methods:This study was done to evaluate the clinicopathological pattern of 6 cases of EGs of the skull diagnosed at a tertiary care hospital. All patients of EG were included with the help of medical records over a 5-year period that is, November 2009 to November 2014. They all had been preoperatively evaluated by skull X-ray and computed tomography. To rule out a multifocal disease scintigraphy was performed in all cases preoperatively. Surgical excision was performed, and EG was diagnosed on histopathology and immunohistochemistry.Results:There was a male predominance. Parietal bone was the most common affected bone. Total excision of the lesion was performed in all cases. No patient received postoperative radiotherapy. The follow-up period ranged from 6 months to 3 years. No tumor recurrence was noted.Conclusion:With an unknown etiology, nonspecific clinical and radiological findings with diagnosis possible only on histopathological examination, EG needs to be considered in the differential diagnosis as a skull mass, especially in children.

Breast specimens are one of the most frequent entries in our department of pathology. Out of these surgical specimens, fibroepithelial lesions are received almost every day. Aim: To study and provide an overview of fibroepithelial lesions of breast. Further to stratify and classify various fibroepithelial lesions into fibroadenomas and phyllodes tumor. Methodology: All the 386 cases of fibroepithelial lesions received over a period of 3 1/2 years from Jan 2015-June 2018 were retrieved and studied in detail. All the associated histological changes as also the clinical details were noted down. Results: Out of the total 386 fibroepithelial lesions, there were 372 fibroadenomas and 14 phyllodes tumors. Among all phyllodes tumors there was a single case each of borderline phyllodes tumor and malignant phyllodes tumor. Conclusion: Fibroepithelial lesions show a wide range of morphology. A strict histopathological assessment with classification leads to proper diagnosis and thus proper treatment in such cases.