Background: There is no general consensus on the normal and pathological values for the posterior tibial slope (PTS). Purpose/Hypothesis: The primary aim of this study was to determine standard values for the PTS in healthy participants using 3-dimensional (3D) computed tomography (CT). A secondary aim was to determine the effect of demographic factors and coronal-plane lower limb alignment on the PTS measurement. The hypothesis was that the PTS would be significantly influenced by demographic factors and coronal-plane lower limb alignment. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A CT-based modeling and analytics system was used to examine and measure lower limb alignment and the PTS in 378 patients (193 male and 185 female; mean age, 58.3 ± 16.4 years [range, 18-92 years]; mean body mass index, 25.0 ± 4.4 kg/m2). The lateral, medial, and global PTS were measured for each patient. All measurements were constructed using algorithm-calculated landmarks, resulting in reproducible and consistent constructs for each specimen. The results were then evaluated based on ethnicity, sex, and hip-knee-ankle (HKA) angle. Results: The study population comprised 219 white and 159 Asian participants. The mean global, medial, and lateral PTS were 6.3° (range, –5.5° to 14.7°; 1% with ≥12°), 6.2° (range, –4.1° to 17.2°; 3% with ≥12°), and 5.3° (range, –4.7° to 16.2°; 2% with ≥12°), respectively. The lateral (Δ = –1.0° [95% CI, 0.6°-1.6°]; P < .0001) and global (Δ = –0.5° [95% CI, 0.0°-0.8°]; P = .0332) PTS were smaller in the female subpopulation. The global PTS was greater (Δ = 1.9° [95% CI, 1.5°-2.3°]; P < .0001) in the Asian subpopulation. The mean HKA angle was 179.6° (range, 170°-190°). The HKA angle was significantly correlated with the medial and global PTS. Specimens with a genu varum knee exhibited a significantly greater global (Δ = 1.2° [95% CI, 0.8°-1.7°]; P < .0001) and medial (Δ = 1.9° [95% CI, 1.3°-2.5°]; P < .0001) PTS. Conclusion: The present study gives a benchmark for the physiological values of the PTS in a healthy population and highlights several factors influencing the PTS, such as ethnicity, sex, and alignment. Anatomic variants with a PTS ≥12° were very uncommon (≤3%) in our Asian and white groups and thus could be considered as pathological. The PTS is a crucial anatomic factor for anterior cruciate ligament injuries and reconstruction. A general consensus is lacking regarding the cutoff for abnormal values, thus guiding standard of care. This study investigated the dispersion of global, medial, and lateral posterior plateau tibial angles in a large population representing a range of demographic diversity.

Background: Many reference axes are used to evaluate rotation of the femoral component during total knee arthroplasty, including the Whiteside line, surgical transepicondylar axis (sTEA), anatomical transepicondylar axis (aTEA), posterior condylar axis externally rotated 3° (PCA+3°ER), sulcus line, and femoral transverse axis (FTA). There is no consensus about which of these axes is most accurate. Methods: The Stryker Orthopaedic Modeling and Analytics (SOMA) database was used to identify 2,128 entire-femur computed tomography (CT) scans. The Whiteside line, aTEA, PCA+3°ER, sulcus line, and FTA were constructed according to published guidelines. Every axis was compared with the sTEA, which is widely regarded as the gold standard reference axis for rotation of the distal part of the femur but has low intraobserver and interobserver reliability intraoperatively. Results: The PCA+3°ER differed from the sTEA by a mean (and standard deviation) of 0.60° ± 1.64°; it was the most accurate but also had the highest degree of intersubject variability. The mean PCA-sTEA angle was 2.40°, close to the accepted “rule of thumb” of 3°. This value was significantly higher in women (2.64° ± 1.74°) than in men (2.18° ± 1.52°; p < 0.001). The Whiteside line differed from the sTEA by a mean of 1.90° ± 1.38°, and the sulcus line differed from the sTEA by a mean of 1.94° ± 1.49°; neither of these values varied significantly with sex or ethnicity. The FTA differed from the sTEA by a mean of 2.04° ± 1.50°. Least accurate was the aTEA, which differed from the sTEA by a mean of 2.05° ± 1.33°. The combination of 3 axes that are readily available intraoperatively (the Whiteside line, aTEA, and PCA+3°ER) differed from the sTEA by a mean of 1.80° ± 0.70°. Conclusions: In the largest study of its kind, analysis of CT scans of 2,128 femora revealed that no 1 axis could serve as a marker of femoral component rotation with both high accuracy and low variability. Utilizing a combination of 3 methods (PCA+3°ER, the Whiteside or sulcus line, and aTEA) to maximize accuracy and sex and ethnic generalizability when positioning the femoral component is recommended. Clinical Relevance: A large-scale study using a CT-based biomorphometric database demonstrated that use of a combination of 3 axes (PCA+3°ER, the Whiteside or sulcus line, and aTEA) was the optimal strategy for judging femoral component rotation.

Purpose Given the goal of achieving optimal correction and alignment after knee arthroplasty or high tibial osteotomy, literature focusing on the inter-individual variability of the native knee, tibia and femur with regards to the coronal or sagit-tal alignment is lacking. The aim of this study was to analyse normal angular values in the healthy middle-aged population and determine differences of angular values according to inter-individual features. The first hypothesis was that common morphological patterns may be identified in the healthy middle-aged non-osteoarthritic population. The second hypothesis was that high inter-individual variability exists with regards to gender, ethnicity and alignment phenotype. Methods A CT scan-based modelling and analysis system was used to examine the lower limb of 758 normal healthy patients (390 men, 368 women; mean age 58.5 ± 16.4 years) with available data concerning angular values and retrieved from the SOMA database. The hip-knee-ankle angle (HKA), lateral distal femoral angle (LDFA), medial proximal tibial angle (MPTA), posterior distal femoral angle (PDFA), posterior proximal tibial angle (PPTA) and non weight-bearing joint line convergence angle (nwJLCA) were then measured for each patient. Results were analysed for the entire cohort and based on gender, ethnicity and phenotype.

Our data confirm the presence of asymmetry of proximal femurs, which is mostly independent of demographic parameters. In cases where contralateral templating is used, such asymmetry may lead to inaccurate anatomical restoration of the hip if the templated sizes are routinely implanted. However, the clinical impact cannot be determined from our investigation. Cite this article: Bone Joint J 2018;100-B:839-44.

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