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Amaç Postmenopozal hasta populasyonunda endometrial örnekleme sonuçlarının değerlendirilmesi ve yetersiz endometrial örnekleme sıklığının belirlenmesi amaçlanmıştır. Gereç ve Yöntem Bu retrospektif çalışmada Bursa Şehir Hastanesi kadın hastalıkları ve doğum bölümüne Temmuz 2019 ve Mart 2021 tarihleri arasında başvuran postmenopozal dönemdeki 825 hastadan alınan endometrial biyopsi sonuçları değerlendirilmiştir. Bulgular Postmenopozal dönemde olan 825 hastadan alınan 922 endometrial örnekleme sonucu değerlendirildi. Hastaların yaş ortalaması 56.96±7.21 olup, ortalama menopoz süresi 7.43±7.14 yıldır. Hastalardan alınan 1. endometrial örneklemenin histopatolojik değerlendirmesi yapıldığında 25.45 % yetersiz endometrial örneklemeye rastlanırken postmenopozal kanama şikayeti ile başvuran hasta grubunda ise bu oran %21.61 dir. En sık endometrial patoloji endometrial polip (22.1%) olup çalışma grubumuzda malignite sıklığı %6.18 idi. Alt grup analizlerde malignite görülme sıklığı >60 yaş grubunda daha yüksek (%18.80) iken yaş ile birlikte yetersiz endometrial örneklemenin de arttığı belirlenmiştir. Birinci endometrial örnekleme sonucu yetersiz olan hastaların sadece %20 sinden tekrar biyopsi alınabilmiştir. Bu hastalardan 3 ünde endometrium kanseri ve 1 hastada atipili endometrial hiperplazi varlığı tespit edilmiştir. Sonuç Artan yaş ile birlikte endometrium kanseri sıklığı artmasına rağmen yetersiz endometrial örneklemenin de arttığı gözlenmiştir. Özellikle bu hasta populasyonunda endometrium kanseri risk faktörlerini de göz önünde bulundurarak takiplere gelmesi konusunda yeterli bilgilendirmenin yapılması önem taşımaktadır.

Purpose Based on the fact that Coronavirus Disease 2019 (Covid-19) is assosiated with many hemocytometric changes, in this clinical trial we aimed to investigate the effect of this underlying inflammatory process on the frequency of miscarriage.Methods This is a retrospective cohort study. Patients with laboratory-confirmed Covid-19 infection before the 20th gestational week were determined as the study group. Healthy pregnant women in their early pregnancy were determined as the control group. Hematological parameters of all patients included in the analysis were evaluated.ResultsA total of 176 pregnant women with confirmed Covid-19 infections were evaluated, of which 117 were included in the analysis. 117 healthy pregnant women were determined as the control group. There was no difference between the groups according to demographic characteristics. The median white blood cell (WBC) and lymphocyte levels were lower in patients with Covid-19 infection (p<0.001, p<0.001). The value of platelet/lymphocyte ratio (PLR) was higher in the group with Covid-19 infection (160.95 vs 132.42, p<0.001). It was also determined that the median plateletcrit level was lower in the group with Covid-19 infection (p<0.001). The miscarriage rate in the Covid -19 infection group and control group was 14.2% and 9.4%, respectively. (p=0.220).ConclusionCovid-19 infection presents with low lymphocyte count and plateletcrit values ​​in pregnant women, and an increase in PLR rates in relation to the severity of the disease is observed. Although not statistically significant, Covid-19 infection was associated with increased miscarriage rates in our study.

Aim: Maternal mortality rates represent an important indicator of global health. An essential factor impacting maternal health during pregnancy is preeclampsia. The theses written on preeclampsia in gynecology and obstetrics were evaluated within the scope of the study. This study aimed to reveal the thematic development and knowledge structure of the theses published on preeclampsia. It aimed to reveal the thematic development and knowledge structure of the theses published in this field. Methods: Within the scope of this study, social network analysis was carried out based on the keywords obtained from the theses prepared with the target of preeclampsia. Theses included in the study were accessed via https://tez.yok.gov.tr/UlusalTezMerkezi/. The studies that include the phrase "preeclampsia" in the title were selected for examination, and the keywords obtained from these studies were listed. Results: The concept with the highest degree of centrality and betweenness centrality is "preeclampsia," as expected. Following the keyword "severe preeclampsia," the keywords "pregnancy." It is observed that the betweenness centrality values of the "severe preeclampsia," "pregnancy," and "endocan" keywords are high compared to the degree centrality values. Conclusions: Through this study, researchers can design innovative topics and questions and concentrate on subjects not often emphasized to develop more valuable research on preeclampsia.

Objectives: Endometrial hyperplasia is a pathology that often represents with abnormal uterine bleeding and develops under the influence of unopposed estrogen. In this study, the response to cyclic medroxyprogesterone acetate (MPA) treatment in endometrial hyperplasia without atypia, which is known to have a good response to progestagen agents, was retrospectively evaluated. Methods: Control endometrial biopsy results of 111 patients who were initiated cyclic MPA treatment due to endometrial biopsy results of endometrial hyperplasia without atypia were evaluated after 3 months of treatment. Endometrial hyperplasia free biopsy results after treatment were accepted as a successful treatment in those patient. Results: Control biopsies revealed proliferative endometrium in 37 (33.3%) patients, secretory endometrium in 34 (30.6%) patients, inactive endometrium in 9 (8.1%) patients, endometritis in 4 (3.6%) patients, endometrial hyperplasia without atypia in 26 (23,4%) patients, and endometrial hyperplasia with atypia in 1 (0.9%) patient. Our response rate to treatment was 75.7% (84/111) and the persistence was found to be 23.4% (26/111). In patients with a positive response to treatment (n = 84), the mean age was 45.15 ± 5.19 years and in patients with no response to treatment (n = 27) the mean age was 45.56 ± 6.41 years, and there was no difference between the two groups in terms of average age. Conclusions: Although the use of cyclic MPA in the treatment of endometrial hyperplasia without atypia is an effective treatment method, we believe that better results will be achieved in the use of more than 3 months duration.

Objectives: An ectopic pregnancy (EP) occurs when a fertilized ovum implants outside the endometrial cavity. We investigated the creatine kinase (CK) enzyme in conservatively treated EP to determine the resolution time and predict cases that may progress to surgical intervention. Methods: We include 43 patients with stable vital signs at recruitment. All participants were examined by using transvaginal ultrasound (TVUS). Beta human chorionic gonadotropin (β-hCG) and creatine kinase (CK) levels were also measured. In cases diagnosed with EP, intramuscular methotrexate (MTX) at a dose of 50 mg / m2 was administered and monitored with β-hCG titers. Follow-up continued until β-hCG titer became negative, or surgery became mandatory due to acute abdominal pain. Results: The mean β-hCG Level in the presence of an adnexal mass was statistically significantly higher than the mean level in patients in whom TVUS failed to define a mass. The mean β-hCG level in the surgical exploration group of patients was significantly higher than in those who did not require surgery. At a cut-off of 6486 mIU/mL, β-hCG could predict the emergence of acute abdomen with a sensitivity of 75% and a specificity of 94.3%. We examined CK level to contribute the test's specificity, but we found no difference among cases with and without surgical exploration. Conclusions: In patients treated conservatively for EP, CK levels at the outset neither predict an acute abdomen to emerge nor shed light on the resolution period in patients who respond to medical therapy.