We can conclude that the hepatoprotective activity of Aegle marmelos was due to its antioxidant effect as evidenced by increasing activity of antioxidant enzymes with enhanced hepatic function and significantly changed the physiological parameters.
Diabetes is a metabolic disorder and enhances the glucose level in the blood. The synthetic antidiabetic agents are limited to the management of diabetes due to its adverse effects. The herbal medicines are the alternative and better option for the management of diabetes. Mostly Ayurvedic formulations are polyherbal formulation and impart chief role for the treatment of diabetes. The polyherbal formulation illustrates the combination of two or more herbs in formulation. The herbal components in the polyherbal formulation interacts leading to synergistic antidiabetic effect compared to the individual herb. Frequent available reports show evidence of synergistic effect of polyherbal drugs and their mechanism of action. But due to scanty availability of these reports in electronic libraries the researcher has to search the hard copies which leads to wastage of effort and time. To overcome these lacuna, this article was undertaken to scientifically review the in vitro and in vivo research studies on antidiabetic polyherbal formulations Further, the data presented in this review exploration of synergistic mechanisms of the antidiabetic polyherbal formulation will not only assist researchers to discover new phytomedicines or drug combinations but also support to avoid the possible negative synergy. Additionally, it would assist in clinical research for carrying out clinical trials to assess the efficacy of these herbal combinations and guide in understanding their synergistic mechanisms.
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Introduction:The objective is to investigate the preliminary phytochemical and physicochemical properties of Woodfordia fruticosa Kurz roots. W. fruticosa, commonly called as Dhavi, is a large beautiful tree, about 10 ft long, belongs to the family Lythraceae. These studies were performed because, before any experimental and clinical trial, phytoconstituents present in the plant should be known. Material and Methods: The root of W. Fruticosa contains protein, fixed oil, glycoside, carbohydrate, terpenoid, steroid, tannin, and saponin. The physiochemical analysis of W. fruticosaroot was also performed which includes ash value, loss on drying and extractive value determination. Result and Discussion: Total ash value, acid-insoluble ash, and water-soluble ash value were 6.5 % w/w, 2 % w/w, and 0.5 % w/w. Loss on drying was 4.4 % w/w, and extractive value was 3.4 % w/v in water and 6.4 % w/v in ethanol. Conclusion: This study revealed that these parameters will be useful in the identification and quality control of the genuine plant material or crude drug.
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