Abstract. In recent years, energy consumption has become a critical issue in the developed and developing countries. Residential buildings are one of the most users of energy in the construction sector that use the highest share of energy. This paper aims at evaluating the effect of four factors that are temperature, humidity, airflow and pressure on the cooling load in the residential buildings. To achieve this goal, statistical experimental design is used to determine the optimum setting of factors that result in optimum energy usage. Simulation software and energy analysis is used to simulate a two-storey building in Malaysia as the case of study. Final results showed that the temperature, humidity and interaction between them have the most significant effect on the energy cooling load. Moreover, to obtain the minimum value of cooling load the temperature and humidity should be equal to A=20 Celsius degree and B=60% respectively. In addition, the other two insignificant factors, airflow and pressure should be placed at the high level which are equal to C=3 cubic meters per hour, and D=6 Pascal (P) respectively.
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