Electroencephalogram (EEG) is a common base signal used to monitor brain activities and diagnose sleep disorders. Manual sleep stage scoring is a time-consuming task for sleep experts and is limited by inter-rater reliability. In this paper, we propose an automatic sleep stage annotation method called SleepEEGNet using a single-channel EEG signal. The SleepEEGNet is composed of deep convolutional neural networks (CNNs) to extract time-invariant features, frequency information, and a sequence to sequence model to capture the complex and long short-term context dependencies between sleep epochs and scores. In addition, to reduce the effect of the class imbalance problem presented in the available sleep datasets, we applied novel loss functions to have an equal misclassified error for each sleep stage while training the network. We evaluated the performance of the proposed method on different single-EEG channels (i.e., Fpz-Cz and Pz-Oz EEG channels) from the Physionet Sleep-EDF datasets published in 2013 and 2018. The evaluation results demonstrate that the proposed method achieved the best annotation performance compared to current literature, with an overall accuracy of 84.26%, a macro F1-score of 79.66% and κ = 0.79. Our developed model can be applied to other sleep EEG signals and aid the sleep specialists to arrive at an accurate diagnosis. The source code is available at https://github.com/SajadMo/SleepEEGNet .

Electrocardiogram (ECG) signal is a common and powerful tool to study heart function and diagnose several abnormal arrhythmias. While there have been remarkable improvements in cardiac arrhythmia classification methods, they still cannot offer acceptable performance in detecting different heart conditions, especially when dealing with imbalanced datasets. In this paper, we propose a solution to address this limitation of current classification approaches by developing an automatic heartbeat classification method using deep convolutional neural networks and sequence to sequence models. We evaluated the proposed method on the MIT-BIH arrhythmia database, considering the intra-patient and inter-patient paradigms, and the AAMI EC57 standard. The evaluation results for both paradigms show that our method achieves the best performance in the literature (a positive predictive value of 96.46% and sensitivity of 100% for the category S, and a positive predictive value of 98.68% and sensitivity of 97.40% for the category F for the intra-patient scheme; a positive predictive value of 92.57% and sensitivity of 88.94% for the category S, and a positive predictive value of 99.50% and sensitivity of 99.94% for the category V for the inter-patient scheme.). The source code is available at https://github.com/SajadMo/ECG-Heartbeat-Classification-seq2seq-model 1 .

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Key Points Question How have medications been used recently in the management of symptoms and comorbidities of autism spectrum disorder (ASD)? Findings This population-based cohort study of 26 722 individuals with ASD in the US retrospectively assessed the most common medications used to treat their symptoms and comorbidities during 6 years. Medication type and frequency varied considerably, depending on the comorbidity diagnosed, and individual drug regimens shifted frequently within medication classes over time. Meaning Many individuals with ASD undergo treatment with a wide variety of medications on a trial basis, resulting in frequent changes in drug regimens over time as clinicians attempt to manage associated symptoms and comorbidities.

The complexity of the patterns associated with Atrial Fibrillation (AF) and the high level of noise affecting these patterns have significantly limited the current signal processing and shallow machine learning approaches to get accurate AF detection results. Deep neural networks have shown to be very powerful to learn the non-linear patterns in the data. While a deep learning approach attempts to learn complex pattern related to the presence of AF in the ECG, they can benefit from knowing which parts of the signal is more important to focus during learning. In this paper, we introduce a two-channel deep neural network to more accurately detect AF presented in the ECG signal. The first channel takes in a preprocessed ECG signal and automatically learns where to attend for detection of AF. The second channel simultaneously takes in the preprocessed ECG signal to consider all features of entire signals. The model shows via visualization that what parts of the given ECG signal are important to attend while trying to detect atrial fibrillation. In addition, this combination significantly improves the performance of the atrial fibrillation detection (achieved a sensitivity of 99.53%, specificity of 99.26% and accuracy of 99.40% on the MIT-BIH atrial fibrillation database with 5-s ECG segments.) 1 .

This paper studies the problem of spectrum shortage in an unmanned aerial vehicle (UAV) network during critical missions such as wildfire monitoring, search and rescue, and disaster monitoring. Such applications involve a high demand for high-throughput data transmissions such as real-time video-, image-, and voice-streaming where the assigned spectrum to the UAV network may not be adequate to provide the desired Quality of Service (QoS). In these scenarios, the aerial network can borrow additional spectrum from the available terrestrial networks in trade of a relaying service for them. We propose a spectrum sharing model in which the UAVs are grouped into two classes of relaying UAVs that service the spectrum owner and the sensing UAVs that perform the disaster relief mission using the obtained spectrum. The operation of the UAV network is managed by a hierarchical mechanism in which a central controller assign the tasks of the UAVs based on their resources and determine their operation region based on the level of priority of impacted areas and then the UAVs autonomously fine-tune their position using a modelfree reinforcement learning algorithm to maximize the individual throughput and prolong their lifetime. We analyze the performance and the convergence for the proposed method analytically and with extensive simulations in different scenarios.INDEX TERMS Autonomous UAV networks, multi-agent systems, Q-learning, reinforcement learning, spectrum sharing.

This study proposes a deep learning model that effectively suppresses the false alarms in the intensive care units (ICUs) without ignoring the true alarms using single-and multimodal biosignals. Most of the current work in the literature are either rule-based methods, requiring prior knowledge of arrhythmia analysis to build rules, or classical machine learning approaches, depending on hand-engineered features. In this work, we apply convolutional neural networks to automatically extract time-invariant features, an attention mechanism to put more emphasis on the important regions of the input segmented signal(s) that are more likely to contribute to an alarm, and long short-term memory units to capture the temporal information presented in the signal segments. We trained our method efficiently using a two-step training algorithm (i.e., pre-training and fine-tuning the proposed network) on the dataset provided by the PhysioNet computing in cardiology challenge 2015. The evaluation results demonstrate that the proposed method obtains better results compared to other existing algorithms for the false alarm reduction task in ICUs. The proposed method achieves a sensitivity of 93.88% and a specificity of 92.05% for the alarm classification, considering three different signals. In addition, our experiments for 5 separate alarm types leads significant results, where we just consider a single-lead ECG (e.g., a sensitivity of 90.71%, a specificity of 88.30%, an AUC of 89.51 for alarm type of Ventricular Tachycardia arrhythmia) 1 .