Background: Histopathological lesions have been widely used as biomarkers for health evaluation of organism exposed to pollutants and can be used as warning symptoms for organism health. There are few reports regarding histomorphological changes in kidney following pesticide chlorpyrifos exposure which has prompted us to undertake this study. Methods: The present study was conducted on 45 inbred adult Wistar albino rats of either sex, weighing 145 – 165 gms. These animals were randomly divided into 3 groups A, B, C. Oral Chlorpyrifos was given to the experimental groups B and C in dose of 5 mg/kg body weight and 10 mg/kg body weight respectively. Group A served as control and was left as such. 3 animals from each group were sacrificed after 1 week, 2nd week, 4th week, 6th week and 8th week of initiation of experiment to see the histological changes in the kidney architecture. Results: Group A shows no histological alterations. Group B – No histological alterations in the kidney after 1 week. From 2 weeks-8 there was shrinkage of glomerulus at initial stages of treatment, tubular dilation, glomerular hypercellularity, hypertrophy of tubular epithelium, degeneration of renal tubules, deposition of eosin positive substance in the glomerulus and renal tubules. There were infiltration of lymphocytes in the interstitium and increased vascularity in the form of dilated vessels fibrosis and interstitial oedema. All these changes were suggestive of glomerulonephritis, acute tubular necrosis and interstitial nephritis leading to acute renal failure progressing to chronic renal failure with increasing duration. In Group C – the Kidneys of 1 week Chlorpyrifos treated rats exhibited shrunken glomeruli and hypertrophy of renal tubular epithelium. From 2nd week- 8thweek, the changes seen were more pronounced than Group B Conclusion: The present study showed that significant histomorphological changes were caused in the kidneys of rats administered with Chlorpyrifos. These changes were markedly different from the control rats. Hence this study brought into light the renal toxicity induced by chlorpyrifos which was found to be significant at high dose level. [Int J Res Med Sci 2013; 1(4.000): 465-475

The aim of this study is to determine the percentage of septal deformities in symptomatic patients in Kashmiri population, identified at otolaryngology clinic of a referral & a teaching tertiary care hospital SKIMS Medical College, Bemina, Srinagar, where 429 patients with nasal septal deviation were identified. All of the patients underwent nasal examination by anterior rhinoscope and nasal endoscopy. Pathological septal deformities were identified & grouped into five types by using SL classification. The frequency of nasal septal deformation has been found to be 151 (35.19%) in males and 278 (64.80%) in females .The age incidence showed that most of the patients between second and fifth decades. The distribution of the five types of septal deformity was 19%, 3.5%, 10.48%, 6.75%, 0.93% & Combinations 60.10% (9.3%, 20.97%, 8.39% and 21.44%) respectively. The most common presentation in overall patients were nasal obstruction 80% and headache 50%. Nasal septal deviation was more prevalent in females. Nasal obstruction was the most common presenting complaint in all over types of nasal septal deviation. So, early diagnosis and intervention can avoid the related complications and thus help normal life and learning.

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Background: Overcrowding, poor hygiene, socio-economic status, climate, lack of resources to avail medical facilities, poor medical awareness have their bearing on the incidence of hearing loss. The family of each hearingimpaired child has its own cultural, social, educational, and financial background, and its own special needs. The aim of this study is to determine the percentage of hearing impaired school going children in Ghaziabad city. Methods:The material for the present study were a representative sample constituting 1000 school children selected from various localities of Ghaziabad city within age group of 6-12 years. The children belonged to all the strata of society and children from both sexes were evaluated for hearing loss and its underlying etiological factors. Children were subjected to detailed ENT examination in our OPD. Results: In the present study sample the incidence of hearing loss is 9.3%. The maximum cases 60.22% belonged to the low socio-economic strata. A statistically significant difference of distribution by gender was noticed with a male preponderance (61.29%) as against 38.71% for females. The hearing loss in majority of cases was of a mild degree i.e., 26 to 45 dB (34.41%) of which majority of cases (87.10%) had conductive loss. Wax was the commonest cause of hearing loss (41.94%). CSOM was found in 21.50 % of all cases. Peak prevalence of hearing loss was found at 8 years of age, again declining after that from 20.43 % to 5.38 % by 12 years of age. Also it was observed that 59.14% children were living in crowded localities of city & 40.86% were living in non-crowded/open locality which is again statistically significant (P ≤0.05). Conclusion:The inferences drawn from the present study substantiates the view point of earlier workers that school screening is the most effective method of diagnosing deafness in school going children and should be extended to all schools in all the areas. Proper assessment and diagnosis of hearing loss in children at a very early age is important because an early diagnosis determines the efficacy of methods used for the correction of the hearing loss. Also early diagnosis of hearing impairment is a key to proper rehabilitation. The cases reporting to the hospital for treatment and rehabilitation can be regarded as the tip of the ice-berg and can have more management difficulties when compared to sub-clinical cases.

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Background: Electrolyte disorders are common in patients in the emergency department and have been associated with increased morbidity and mortality. In this respect sodium, potassium and calcium are the most important cations, whose improper adjustment may cause severe disorders in neuromuscular, gastrointestinal, respiratory and cardiovascular systems. Aims & Objectives: This study intends to assess the prevalence of electrolyte abnormalities in patients hospitalized in emergency department of Government Medical College, Srinagar. Materials and Methods: A cross-sectional descriptive study was conducted among 11,000 patients admitted in emergency department. Simple stratified sampling was done to select the patients hospitalized in emergency ward. A semi-structured questionnaire containing the socio-demographic variables was prepared. Meanwhile, biochemical test for sodium, potassium, calcium, bicarbonate, serum creatinine, and blood urea were carried out. The data was collected and analyzed using SPSS 11.5 version. Results: Frequency distribution of electrolyte abnormalities was as follows: Hyponatremia 49%, hypernatremia 7%, hypokalemia 36%, hyperkalemia 16%, hypocalcemia 6% and hypercalcemia 3%. Bicarbonate levels were: low levels 18%, high levels 9%. 21% and 16% of patients had blood urea and creatinine more than the normal range respectively. A total of 42% of patients hospitalized in emergency department had nonsurgical problems and 58% of the patients had surgical problems. The most common electrolyte abnormality was related to variation in serum sodium and potassium levels in the form of hyponatremia and hypokalemia. Conclusion: The prescription of fluid therapy in emergency is a common clinical event. The foundations that underpin such therapy should be understood by all clinicians involved in the short-term care of patients admitted in emergency. The routine measurement of the renal function tests and electrolytes is thus warranted in all patients hospitalized in emergency departments for the early detection of any possible derangement(s).

Introduction: Stature is considered as one of the important parameters for personal identification. So, Stature reconstruction is important as it provides forensic anthropological estimation of the height of a person in the living state which plays a vital role in the identification of individual remains. Aim: The aim of the present study was to investigate the association of hand length with height and to show if height could be predicted using hand length measurements in students of SKIMS Medical college. Methodology: The study of the anthropometric characteristics of 100 Medical College students of ages between 18-23 years of SKIMS Medical college, bemina with no obvious deformities or previous history of trauma to the spine or hand was undertaken. The study of these medical students, males (n=50) & females (n=50) was investigated. The anthropometric characteristics of their height and hand length were measured, analysed statistically for any significant difference, and correlation between the parameters studied. Results: The results show some significant differences between the anthropometric parameters, Pearson's correlation analysis was used and showed a strong positive correlation, which means that high X variable scores go with high Y variable scores.(R is 0.8229) and it is significant. Results from the present study show that there was a positive correlation between height and hand length indicating that height could be predicted using hand length. Conclusion: As age groups increase the mean length of hand also increase, so there is direct relation between length of hand and age groups. Definite proportion also exists between the height and hand length in an individual at all ages, irrespective of the sex. Height of an individual is 9 times the height of hand length. Thus we can predict height from hand length when it is difficult or not possible to measure height directly.

Aim:The present study is a prospective study that looks into the prevalence of chorda tympani nerve injury and related symptoms following varying degrees of trauma to the nerve during four common types of middle-ear operations; namely, Tympanomastoid operations, myringoplasty, Tympanoplasty and Exploratory tympanotomy. Materials and Methods: 178 patients who underwent middle ear cleft surgery were included in this prospective study. Childrens below 20 years and patients with other potential cause of taste disturbance were excluded. Patients were given a single questionnaire, so as to assess their post-operative taste disturbance. Patient name, Age, Sex, Type of middle ear surgery, side of surgery were recorded. Any change in sense of taste immediately (after 2-4 weeks) or delayed (2-3 years)were recorded. Results: The number of patients with Chorda tympani nerve-related symptoms varied widely between these four groups. Increased occurrence of the nerve related symptoms were observed in Tympanomastoid and Myringoplasty, and a prolonged recovery time were observed in the tympanomastoid group. Stretching of the nerve produced more symptomatic cases than thermal injury or drying. Conclusion: It is important to inform patients about the possibility of Chorda Tympani Nerve injury during middle-ear operations, and it should also be emphasized that symptoms related to Chorda Tympani Nerve injury can occur irrespective of the type of damage to the nerve.