Assessing floods and their likely impact in climate change scenarios will enable the facilitation of sustainable management strategies. In this study, five machine learning (ML) algorithms, namely (i) Logistic Regression, (ii) Support Vector Machine, (iii) K-nearest neighbor, (iv) Adaptive Boosting (AdaBoost) and (v) Extreme Gradient Boosting (XGBoost), were tested for Greater Hyderabad Municipal Corporation (GHMC), India, to evaluate their clustering abilities to classify locations (flooded or non-flooded) for climate change scenarios. A geo-spatial database, with eight flood influencing factors, namely, rainfall, elevation, slope, distance from nearest stream, evapotranspiration, land surface temperature, normalised difference vegetation index and curve number, was developed for 2000, 2006 and 2016. XGBoost performed the best, with the highest mean area under curve score of 0.83. Hence, XGBoost was adopted to simulate the future flood locations corresponding to probable highest rainfall events under four Representative Concentration Pathways (RCPs), namely, 2.6, 4.5, 6.0 and 8.5 along with other flood influencing factors for 2040, 2056, 2050 and 2064, respectively. The resulting flood risk probabilities are predicted as 39–77%, 16–39%, 42–63% and 39–77% for the respective years.