Background: We investigated the relationship between myometrial invasion and the prognostic factors on overall and progression free survival in endometrial carcinoma.Methods: 122 cases operated with endometrial cancer were included into the study. Progression-free survival and overall survival were evaluated according to degree of myometrial invasion. We also investigated the relationship between myometrial invasion and prognostic factors. Results: The 5- year progression-free survival rate was 90 % in stage I, 66 % in stage II, 32 % in stage III and 60 % in stage IV. The 5- year overall survival rate was 95 % in stage I, 89 % in stage II, 49 % in stage III and 30 % in stage IV. The progression free survival and overall survival for patients with more than 50 % myometrial invasion were detected 67 % at 58 months and 66 % at 60 months, respectively. The clinicopathological variables that significantly correlated with myometrial invasion of more than 50 % were as follows: pelvic lymph node metastasis (p: 0,00029-OR: 11.2), cervical stromal invasion (p: 0008-OR:7.9), LVSI (p< 0.0001-OR: 16.5).Conclusion: The depth of myometrial invasion is one of the most important prognostic indicators and determinants of therapy in endometrial cancer. Keywords: Endometrial carcinoma; Progression free survival; Overall survival; Prognostic factors.
Objectives: The aim of this study was to investigate the benefits of the newly revised "The international federation of gynecology and obstetrics (FIGO), 2009" sytem and whether there was a difference in new system comparison to 1988 FİGO staging sytem for endometrial carcinoma. Methods: A total of 132 patients who underwent complete surgical staging for endometrial cancer were enrolled retrospectively. Those patients' overall survival and disease free survival were compared with 1988 and 2009 staging system. Results: The five year overall survival (OS) rates for patients with 1988 FIGO stage 1 and 2 were 97% and 100%, respectively. In 2009 system, the OS rates for 1 and 2 were 97% and 100%, respectively. There was no statistically significant differences between stage 1 and stage 2 for OS rates in 1988 and 2009 as well. Conclusions:The newly revised system could be less complex for understanding, but it does not discriminate survival rates better, especially in earlier stages. A new staging system and uniform surgical staging could be discussed.
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