Chemicals and supplies Dexmedetomidine reference stock solution was a pharmaceutical product Dexdor 200 µg / 2 ml (Orion Pharma). Internal standard (Medetomidine-d3 Hydrochloride, 100 µgml-1 , Lot number2-GJR-98-2) was a commercial solute on manufactured by Toronto Research Chemicals, Inc., Canada. HPLC-grade methanol was purchased from Honeywell, Riedel-de-Haën, Germany, Water was purified using a Merck Millipore Milli-Q® Advantage A10® Synthesis water purification system. Preparation of calibration standards and quality control samples Stock solutions of dexmedetomidine and the internal standard were first diluted with a mixture of water and methanol (1:1, v/v) and then with water to achieve desirable concentrations to be used for
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