A new sensitive colorimetric method for determination of aspirin tablet in aqueous solution. The method is depending on the formation of a yellow colored azo dye by diazotization of 2, 4-dichloroaniline followed by azo-coupling reaction between the resulting product and acetylsalicylic acid. The lambda max of azo dye at 527nm. Beer's low was found to be obeyed in the concentration range of 2-25µg/mL with rang of molar absorptivity between (2935) Lmol -1 cm -1 .Aspirin tablet from different sources industrial companies (SDI, NDI) using high performance liquid chromatography (HPLC) with reversed-phase (ODS-C18) column at low wave length of Uv-visible detection (280nm).the acetylsalicylic acid was eluted for 5 minute at flow rate 2ml/min. The retention time of acetylsalicylic acid was observed at 4.11 minutes. The concentration of the different above companies were gave good relationship between area under the peak (AUP) and acetylsalicylic acid content (p1> 0.001). The comparing of the all values of aspirin tablets in (SDI, NDI) between the above methods were evaluated a good accuracy while the new colorimetric spectrophotometric method for the determination of acetylsalicylic acid (ASA) in pharmaceutical formulations developed procedure was successfully applied to the rapid determination of acetylsalicylic acid in commercial pharmaceutical preparations. The unique features of this procedure are that determination can be carried out at room temperature and analysis time is short. The newly developed method is simple, inexpensive and efficient for use in the analysis of a large number of samples.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.