An ongoing question is what constitutes the characteristics of a project manager. This is the subject of many studies. The characteristics, skills, abilities and knowledge of project managers—essential factors in a project’s success—describe their level of competency. This study aims to assess the relationship between project manager competencies and project complexity in the information technology (IT) sector. In total, 21 semi-structured interviews were conducted with senior practitioners associated with complex IT projects in the private and public sectors. All transcripts were analysed through grounded theory and content analysis, with experts approving the results. Our study identified 41 competencies within project complexity, with these grouped under the following 10 dimensions: project management (PM) knowledge; management skills; interpersonal skills and attributes; professionalism; expertise; emotional skills; contextual skills; influencing skills; team working; and cognitive skills. According to this research, leadership is the core competency of a project manager, while project management knowledge is the most essential of these competency dimensions. This study’s findings can assist both academics and practitioners in simplifying the complexity of projects and helping to achieve a project’s objectives.
Several animal experimental and clinical studies have shown the effectiveness of melatonin in the treatment of some symptoms of Parkinson's disease (PD). However, the antinociceptive effect of melatonin against pain associated to PD has not been fully investigated. Thus, the present study investigated the possible antiallodynic and antinociceptive effects of acute and chronic melatonin treatments in Parkinsonian model of rats. This model was created by unilateral injection of 6-hydroxydopamine (6-OHDA) into the left medial forebrain bundle (MFB). The electronic von Frey test was used to analyze the antiallodynic effect of melatonin on this PD animal model. In addition, c-Fos immunostaining was also used as a marker of nociception to evaluate the neuronal activity related to the nociception processing. The results showed that unilateral injection of 6-OHDA induced a significant decrease in paw withdrawal threshold in both ipsilateral and contralateral paws, which indicate mechanical allodynia induction. This allodynia was transitorily reversed by apomorphine as a dopamine agonist. Melatonin treatment significantly increased threshold of allodynia. Melatonin administration of both acutely or chronically significantly downregulated the c-Fos expression of neurons in 6-OHDA treated animals. In conclusion, 6-OHDA treatment can induces a bilateral mechanical hypernociception in rats while melatonin treatment produces profound antinociceptive effect. This finding paves the way to use melatonin as an antinociceptive agent for PD clinically.
The present study was conducted to test the use of the hemiparkinsonian rat, obtained by the unilateral injection of 6-hydroxydopamine (6-OHDA) in the substantia nigra pars compacta (SNc), as a suitable model for the study of pain associated to Parkinson’s disease (PD). For this purpose, 14 days after unilateral injection of saline or 6-OHDA, rats were assessed for behavioral function in the cylinder test, and apomorphine-induced circling test. Thereafter, at 21st day after injection, mechanical nociceptive threshold was compared between 6-OHD-lesioned and sham-operated animals using electronic von Frey test. Our results showed that injection of 6-OHDA in the SNc induced alterations of behavioral motor as ascertained by predominant use of the ipsilateral forepaw in cylinder test and by the expression of contralateral turnings after subcutaneous injection of apomorphine. The mechanical nociceptive threshold was significantly decreased in 6-OHDA-lesioned rats compared to that of sham-operated rats (p <0.05). This response was reversed by apomorphine treatment. In conclusion, hemiparkinsonian rat, obtained by the unilateral injection of the 6-OHDA in the SNc, can be used to investigate pain symptoms and central pain processing mechanisms related to PD.
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