Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism. It is an anthelmintic drug in human as well as in veterinary medicine. This review article represent the various analytical methods which has been reported for estimation of piperazine. The colorimetric , spectrophotometric techniques and chromatographic methods like HPLC and RP HPLC, GC, LC-MS, LC-MS/MS and another methods were reported.
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