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INTRODUCTION: Oral squamous cell carcinoma (OSCC) is the commonest malignancy in oral cavity. Dysregulated inflammatory processes could impose a cancer risk. Cytokines are inflammatory mediators that can induce cell proliferation. Interleukin-10 is a pleiotropic cytokine which has a dual role in cancer pathogenesis. It contributes to tumor growth and in other cases to tumor rejection. OBJECTIVES: To evaluate and correlate the expression of IL-10 in different histopathological grades of OSCC, as well as to assess its serum and salivary levels. MATERIALS AND METHODS: Immunohistochemical (IHC) study using the IL-10 antibody was done on 20 surgical specimens and 5 normal mucosal tissues taken from OSCC patients and healthy individuals, respectively. Serum and salivary levels of IL-10 were also measured with a human IL-10 ELISA Kit in both patients and controls. RESULTS: OSCC biopsies showed immunoreactivity to IL-10, while normal tissues were immunonegative. The IHC staining intensity was directly proportional to the grading of OSCC. Conversely, it showed no significant correlation to the disease stage. The difference in the serum and salivary IL-10 levels in patients and controls was not statistically significant. However, there was a significant correlation between IL-10 tissue expression and its serum and salivary levels in OSCC patients. CONCLUSIONS: IL-10 is expressed in OSCC biopsies. Additionally, the levels of IL-10 in tissue, serum and saliva were correlated to each other. This could reflect the same way of regulation of IL-10 in different parts of the body.

INTRODUCTION: Salivary gland tumors (SGTs) are infrequent tumours accounting for 2-6.5% of all head and neck tumors. They show various clinical behaviours and different histological patterns resulting in a diagnostic dilemma. Insulin like growth factor II mRNA binding protein 3 (IMP3) is an oncofetal protein that plays an important role in tumor invasion and metastases. Several studies proved the prognostic role of IMP3 in different human cancers. However, its role in SGTs still needs to be confirmed. OBJECTIVES: To evaluate IMP3 immunoexpression in benign and malignant SGTs. MATERIALS AND METHODS: IMP3 expression was measured in 44 SGT cases (20 benign and 24 malignant) and 10 normal salivary gland tissues (NSGT). Immunohistochemical (IHC) staining was carried out by the Labeled Strept-Avidin Biotin complex method (LSAB). RESULTS: IMP3 expression was detected in NSGT as well as benign and malignant SGTs with different intensities. The Lowest expression levels were detected in NSGT, while the highest ones were detected in Malignant SGTs. CONCLUSION: IMP3 could be used as a diagnostic marker in SGTs.

INTRODUCTION: The etiology of orofacial swellings could be attributed to the presence of inflammation, congenital developmental malformations and neoplasia. Orofacial swellings may occur in the nasal cavities, paranasal sinuses, ear, eye, facial skin, oral cavity and salivary glands. Swellings of the orofacial region include cysts and tumors. Cysts are divided into developmental and inflammatory types. Tumors are divided into benign and malignant types. OBJECTIVES: Perform clinicopathological correlation of orofacial swellings and assess the frequency of incidence regarding age, sex, site, and type of lesion. MATERIALS AND METHODS: A clinicopathological prospective study was conducted on 100 patients suffering from swellings in the orofacial region attending the outpatient clinic of the oral and maxillofacial surgery department. The histopathological examination was done. Statistical analysis was carried out on the tabulated data using (IBM SPSS 20.0) software. RESULTS: It was found that the incidence of all swellings in males was slightly more than females. The incidence of all swellings in the second and third decades of age. The mandible was the most frequently affected site. Using the histological classification of the World Health Organization (WHO), 32% were classified as cysts, 26% as odontogenic tumors, 25% as non-odontogenic tumors, 11% fibro-osseous lesions and 6% as salivary gland tumors. CONCLUSIONS: Cysts are the most common oral swellings, followed by odontogenic tumors. The treatment modalities were: marsupialization, enucleation, resection, segmental mandibulectomy and hemimandibulectomy. Following surgical removal of jaw swelling, the entire surgical specimen should be examined histopathologically.