Background: A negative attitude toward treatment is a major obstacle to treat bipolar disorder. Objectives: The current study aimed at assessing the reliability and validity of Persian version of drug attitude inventory (DAI-10) in patients with bipolar I disorder and finding its relationship with patients' compliance in order to predict the disorder. Methods: To assess test-retest reliability, 30 outpatients with bipolar I disorder were selected. They were asked to answer the questions at the onset of the study and four to ten days later. Then, the relationship between DAI-10 scores of 82 patients in bipolar disorder patients' follow-up (BDPF) study, and medication possession ratio (MPR) were investigated. The patients were divided into poor and good compliance, and cut off point of the tool was assigned. Positive and negative predictive value of DAI score was also calculated.
Introduction: In this study, the effect of zinc sulfate (ZS) supplement and eight-week continuous training (CT) and interval training (IT) on liver oxidative stress of morphine-dependent rats following withdrawal syndrome (WS) were evaluated. Methods: Seventy Wistar rats were randomly divided into seven groups: control rats, withdrawing rats (WS), withdrawing rats receiving 9mg/kg ZS orally (WS+Z), withdrawing rats under CT (WS+CT), withdrawing rats under IT (WS+IT), withdrawing rats under CT and receiving 9mg/kg zinc sulfate (WS+Z+CT), withdrawing rats under IT and receiving 9mg/kg zinc sulfate (WS+Z+IT). Animals were addicted by 0.4g/l morphine sulfate in 21 days. Animals in the training groups ran on a treadmill and received ZS 5 days/week for 8 weeks. At the end of the study, oxidative stress in liver tissue and liver enzymes were measured by spectrophotometric and ELISA methods. Results: ZS supplement, CT/IT led to decrease DNA damage and malondialdehyde in comparison with morphine group. Also, ZS, CT and IT significantly elevated levels in superoxide dismutase, catalase activity, total antioxidant capacity and thiol groups in the liver of rats in comparison with morphine group. Additionally, it is observed that ZS and CT/IT made a significant reduction in aspartate aminotransferase levels in comparison to the morphine group. Conclusion: CT/IT with ZS because of its antioxidant effects has the potential to be used for decreased withdrawal syndrome complications.
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