ordered alphabetically, † Equal contributions, ordered alphabetically, ‡ Equal senior contributions Building models that can be rapidly adapted to numerous tasks using only a handful of annotated examples is an open challenge for multimodal machine learning research. We introduce Flamingo, a family of Visual Language Models (VLM) with this ability. Flamingo models include key architectural innovations to: (i) bridge powerful pretrained vision-only and language-only models, (ii) handle sequences of arbitrarily interleaved visual and textual data, and (iii) seamlessly ingest images or videos as inputs. Thanks to their flexibility, Flamingo models can be trained on large-scale multimodal web corpora containing arbitrarily interleaved text and images, which is key to endow them with in-context few-shot learning capabilities. We perform a thorough evaluation of the proposed Flamingo models, exploring and measuring their ability to rapidly adapt to a variety of image and video understanding benchmarks. These include open-ended tasks such as visual question-answering, where the model is prompted with a question which it has to answer, captioning tasks, which evaluate the ability to describe a scene or an event, and close-ended tasks such as multiple choice visual question-answering. For tasks lying anywhere on this spectrum, we demonstrate that a single Flamingo model can achieve a new state of the art for few-shot learning, simply by prompting the model with task-specific examples. On many of these benchmarks, Flamingo actually surpasses the performance of models that are fine-tuned on thousands of times more task-specific data.
The heterogeneity in recently published knowledge graph embedding models' implementations, training, and evaluation has made fair and thorough comparisons difficult. To assess the reproducibility of previously published results, we re-implemented and evaluated 21 models in the PyKEEN software package. In this paper, we outline which results could be reproduced with their reported hyper-parameters, which could only be reproduced with alternate hyper-parameters, and which could not be reproduced at all, as well as provide insight as to why this might be the case.We then performed a large-scale benchmarking on four datasets with several thousands of experiments and 24,804 GPU hours of computation time. We present insights gained as to best practices, best configurations for each model, and where improvements could be made over previously published best configurations. Our results highlight that the combination of model architecture, training approach, loss function, and the explicit modeling of inverse relations is crucial for a model's performance and is not only determined by its architecture. We provide evidence that several architectures can obtain results competitive to the state of the art when configured carefully. We have made all code, experimental configurations, results, and analyses available at https://github. com/pykeen/pykeen and https://github.com/pykeen/benchmarking.
Knowledge graphs (KGs) can vary greatly from one domain to another. Therefore supervised approaches to both graph-to-text generation and text-to-graph knowledge extraction (semantic parsing) will always suffer from a shortage of domain-specific parallel graphtext data; at the same time, adapting a model trained on a different domain is often impossible due to little or no overlap in entities and relations. This situation calls for an approach that (1) does not need large amounts of annotated data and thus (2) does not need to rely on domain adaptation techniques to work well in different domains. To this end, we present the first approach to unsupervised text generation from KGs and show simultaneously how it can be used for unsupervised semantic parsing. We evaluate our approach on WebNLG v2.1 and a new benchmark leveraging scene graphs from Visual Genome. Our system outperforms strong baselines for both text↔graph conversion tasks without any manual adaptation from one dataset to the other. In additional experiments, we investigate the impact of using different unsupervised objectives. 1
Bulk whole genome sequencing (WGS) enables the analysis of tumor evolution but, because of depth limitations, can only identify old mutational events. The discovery of current mutational processes for predicting the tumor’s evolutionary trajectory requires dense sequencing of individual clones or single cells. Such studies, however, are inherently problematic because of the discovery of excessive false positive (FP) mutations when sequencing picogram quantities of DNA. Data pooling to increase the confidence in the discovered mutations, moves the discovery back in the past to a common ancestor. Here we report a robust WGS and analysis pipeline (DigiPico/MutLX) that virtually eliminates all F results while retaining an excellent proportion of true positives. Using our method, we identified, for the first time, a hyper-mutation (kataegis) event in a group of ∼30 cancer cells from a recurrent ovarian carcinoma. This was unidentifiable from the bulk WGS data. Overall, we propose DigiPico/MutLX method as a powerful framework for the identification of clone-specific variants at an unprecedented accuracy.
A major challenge in scene graph classification is that the appearance of objects and relations can be significantly different from one image to another. Previous works have addressed this by relational reasoning over all objects in an image or incorporating prior knowledge into classification. Unlike previous works, we do not consider separate models for perception and prior knowledge. Instead, we take a multi-task learning approach by introducing schema representations and implementing the classification as an attention layer between image-based representations and the schemata. This allows for the prior knowledge to emerge and propagate within the perception model. By enforcing the model also to represent the prior, we achieve a strong inductive bias. We show that our model can accurately generate commonsense knowledge and that the iterative injection of this knowledge to scene representations, as a top-down mechanism, leads to significantly higher classification performance. Additionally, our model can be fine-tuned on external knowledge given as triples. When combined with self-supervised learning and with 1% of annotated images only, this gives more than 3% improvement in object classification, 26% in scene graph classification, and 36% in predicate prediction accuracy.
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