The distances from the round window to the oval window and facial nerve are important parameters in identifying a difficult round window niche. Modification of the electrode may be a better option than drilling off the round window margins for insertion of cochlear implant electrodes.

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Tracheostomy is a life-saving procedure performed in both emergency and elective setting. Development of bilateral pneumothorax in adults following tracheostomy is a rare complication. We report a case of bilateral iatrogenic pneumothorax in 33-year-old woman from rural Maharashtra in central India, immediately following emergency mid-level tracheostomy done for post-radiotherapy fi brosis with laryngeal perichondritis and retropharyngeal infection associated with prolonged dyspnea. No pleural injury or posterior tracheal wall injury had occurred. Sudden left-sided chest pain with immediate reoccurrence of dyspnea prompted us to do urgent chest X-ray. Bilateral pneumothorax was identifi ed, more on the left side. The patient was treated with tube thoracostomy. The case is being reported to highlight the possibility of occurrence of this rare life-threatening complication due to the underlying mechanism in any case of emergency tracheostomy.

Cadaveric dissection is the most important learning tool in anatomy. Although many new modalities are coming up for learning anatomy, cadaveric dissection outstands all of these as it helps students to visualize the human body and remains the most realistic way of learning anatomy. The cadavers are preserved using formalin, a potent disinfectant. Even after embalming in 5-10% formalin, the cadaver might still be infectious while using it in the dissection hall (anatomy department). Numerous bacterial species and infectious pathogens might still be seen despite using fixative agents. Several disease-causing agents may remain viable. Earlier reports suggest that there are cases where students and the working staff got infected by HIV, viral hepatitis, tuberculosis, and prion diseases.The main objective of this study is to determine if bacterial species could be recovered from cadavers that are formalin-fixed. Specific regions in the body such as the axilla, perineum, finger clefts, and oral and nasal cavities were chosen for microbiological examination to detect bacterial species. The presence of skin folds in these regions makes them potential sites for the growth of bacteria.Formalin-fixed cadavers can still act as regions for the growth of viable bacteria that can be pathogenic and affect the health of students and anatomists handling them. Proper care should be taken regarding this because students and anatomists working with these cadavers may get exposed to pathogenic organisms which may become harmful or sometimes life-threatening. Some precautions for proper dissemination of cadavers should be taken to provide a complete, safe, and healthy ambiance in the dissection hall.

Acute laryngeal abscess is a rare but potentially lethal condition. There are historic descriptions of its association with systemic illnesses like typhoid fever or as a result of spread of infection following upper respiratory tract catarrh. The etiology of laryngeal abscess in recent times has changed to those with underlying malignancy, trauma due to airway instrumentation, nasogastric intubation, and external beam radiotherapy. Here we report a case of acute laryngeal abscess following catarrh, identical to the historic descriptions, probably the first such report in the modern era, highlighting the importance of its early diagnosis and high index of suspicion, which led to a very good recovery in our patient.

Parkinson's disease (PD) is a syndrome with deterioration of neurons, with its onset starting in the '20s, known as the young beginning of Parkinson's to the late inception of the ailment in the 60s. The majority of the environmental risk associated with PD is age. The pathophysiology of PD is related to the accretion of synuclein alpha (SNCA) protein leading to toxicity. This toxicity further leads to a depletion in dopamine levels, creating both motor and non-motor symptoms. PD is the combination of genetic and environmental risk factors. Linkage and association studies provided data on autosomal dominant and recessive genes linked to PD. Current treatment regimes involve using levodopa, catechol-O-methyl transferase inhibitors, anticholinergics, and monoamine oxidase B (MAO-B) inhibitors. Genetic treatment is done by identifying possible targets. Gene therapy includes silencing, replacing, or correcting the flawed gene with a good gene. This therapy has the advantage of eliminating significant PD symptoms with fewer to no adverse effects than conventional treatment. These targets are organized into disease-modifying or non-disease modifying. The distinction between these two is that disease-modifying treatment stops the degeneration of neurons, while non-disease modifying treatment involves dopaminergic enzyme expression. In non-modifying targets, aromatic L-amino acid decarboxylase (AADC) therapy is used but not as a standalone, so the presentation of AADC, tyrosine hydroxylase (TH), and GTP cyclohydrolase 1 (GCH) is done together as a tricistronic system. With these developments, a drug named prosavin is under clinical phase 1 trial. Diseasemodifying targets involve glial cell-derived neurotrophic factor (GDNF). Direct GDNF delivery reduces PD symptoms. This GDNF infusion technique works with a tetracycline-controlled transactivator. Gene therapy introduction into the treatment of PD would be beneficial as there would be lesser adverse effects seen as linked with conventional treatment involving levodopa, MAO-B inhibitors, and anticholinergics, among a few. This article discusses the genetic basis and genetic model of therapy for PD.

Ramsay Hunt syndrome is the complication of the virus varicella-zoster and the infection caused by it, which shows apparent geniculate ganglion involvement. This article discusses the etiology, epidemiology, and pathology of Ramsay Hunt syndrome. Clinically it may be presented as a vesicular rash on the ear or even in the mouth, pain in the ear, and facial paralysis. Some other rare symptoms may also be present, which are also discussed in this article. Skin involvement is also seen in some cases as patterns due to anastomoses between cervical and cranial nerves. This article provides an overview of how the varicella-zoster virus causes facial paralysis and other neurological symptoms. Knowing about this condition and its clinical features is essential to make an early diagnosis and, thus, provide a good prognosis. A good prognosis is required to reduce the nerve damage, prevent further complications, and start an early therapy of acyclovir and corticosteroid. This review also presents a clinical picture of the disease and its complications. The incidence of Ramsay Hunt syndrome has gradually decreased over time because of the development of the varicella-zoster vaccine and better health facilities. The paper also talks about how the diagnosis of Ramsay Hunt syndrome is made and the various treatment options available. Facial paralysis in Ramsay Hunt syndrome presents differently than Bell's Palsy. If not treated for too long, it may cause permanent muscle weakness and may also cause a loss of hearing. It may be confused with simple herpes simplex virus outbreaks or contact dermatitis.