I C0,Et ( l a -d 1 a; R1 = Me,R2 = H b; R1 = Me,R2 = OMe c ; R 1 = R2 = M e d; R ' = -C5Hll,R2 = H ( 2 a -d 1 ( 3 a -d ) J SCHEME 1 We now describe the transformation of the cyclo-iodide in refluxing acetone gave the N-methyl derivative prop[b]indole (2) into derivatives of the physostigmine (4a) in 13% yield, from which a Rosenmund synthesis ring system. gave deoxyeserine in two steps., In a similar, manner, Heating compound (2a) with 10% potassium hydroxide the cycloprop[b]indoles (2b-d) were converted into the B. Gilbert, '
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