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Cathepsin D (Cath-D) is a soluble lysosomal aspartyl glycoprotease that can degrade the protein components of the matrix and free growth factors therein embedded, thus favoring tumor growth, invasion and angiogenesis. The aim of the present work was to investigate the expression of Cathepsin D as novel prognostic biomarker in human invasive ductal carcinoma (IDC) versus benign tumors and normal breast tissues as well as their correlation with different pathological and histological parameters. Immunohistochemical technique was used to examine the expression of Cath-D in normal, benign as well as in IDC. Present results showed higher expression of Cath-D in IDC comparing to normal and benign breast tissues.

In human steroid sensitive tissue, progesterone receptors (PRs) and estrogen receptors (ERs) have been demonstrated at the mRNA and/or protein levels by using molecular biology and immunohistochemistry techniques. Estrogen and progesterone receptors are present both in endometrial hyperplasia and in neoplastic endometrium. The aim of the present work was to compare the expression of ER and PR as prognostic biomarkers in human endometrial adenocarcinoma versus benign tumors and normal endometrial tissues as well as their correlation with different pathological and histological parameters. Immunohistochemical technique was used to examine the expression of ER and PR in normal, benign as well as in endometrial adenocarcinoma. Present results showed higher expression of ER and PR in endometrial adenocarcinoma comparing to normal and benign endometrial tissues.

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