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Background:The prevalence of Metabolic Syndrome (MS) has been increasing worldwide. Although Uric Acid (UA) Levels are often increased in subjects with MS, it is still unclear whether uric acid plays a causal role for MS or is a marker. The purpose of this study was to examine the association between UA and the MS in Qazvin, Iran.Methods:529 men and 578 women aged 20 – 78 years attended in cross sectional study from September 2010 to April 2011 in Qazvin, Iran. The criteria proposed by new joint Interim societies (JIS) were applied for diagnosis of MS. Hyperuricemia was defined as UA ≥ 7 mg/dL in men and UA ≥ 6 mg/dL in women. Logistic regression analysis was performed to evaluate the relationship between UA quartiles and MS.Results:The prevalence of MS was found to be 39.3%. Prevalence of hyperuricemia was 8.4% in males and 4.1% in females (P=0.004). Mean UA level was higher in males than in females (P<0.001). UA levels increased significantly with an increasing number of MS components in both genders. Prevalence of MS increased across UA quartiles in females; however the increasing trend began from second quartile in males. Using the lowest quartile of UA level as a reference, there were no significant association between UA quartile groups and MS.Conclusion:This study showed that UA levels are not an appropriate predictor of MS in Iranian population. More longitudinal studies are necessary to confirm the role of UA in MS occurrence.

The effect of soy protein with low calorie diet on blood lipids in hyperlipidemic type 2 diabetic patients was studied. Thirty‐two subjects of both sexes, age range 25–65 years, were distributed in 16 cases and 16 controls. All subjects received a low calorie diet based on 1,400 kcal energy, 27% fat, 21% protein and 52% carbohydrate from a registered dietitian for 4 weeks. In addition to a low calorie diet, the case group received soy protein (30 g/d). Both groups significantly lost weight (P < 0.001). Body mass index, waist and hip circumferences were significantly reduced (P < 0.05) after 4 weeks of treatment. The difference between the groups was insignificant. In all subjects who were fasting, blood sugar significantly decreased (P < 0.001). Soy protein was associated with a significant reduction in serum triacylglycerols (24.8%, P < 0.05), whereas an insignificant reduction was seen in total cholesterol and low‐density lipoprotein (7.1 and 3.1%, respectively). No significant change occurred in high‐density lipoprotein cholesterol. PRACTICAL APPLICATIONS Serum lipid abnormalities are an established risk factor for cardiovascular disease in diabetic patients. Because of the side effects of long‐term medications in these patients, soy protein, as a part of healthy diet, may improve their lipid profile.

Background: Cardiovascular Disease (CVD) is developing treacherously along industrialization and development of urbanization Objectives: The aim of this study was to compare cardiovascular risk factors between subjects with and without diabetes mellitus in the Minoodar district of Qazvin. Patients and Methods: This analytical study was conducted on 100 subjects with diabetes and 140 subjects without diabetes in Qazvin from September 2010 to April 2011. Standardized measurements were available for waist circumference (WC), blood pressure (BP), fasting serum cholesterol, high-density lipoprotein cholesterol (HDL), and triglycerides (TGs). Cardiovascular risk factors were defined according to the diagnostic criteria proposed by the national cholesterol education program. Data were analyzed using the t-test, Mann-Whitney U test, and Chi-square test. Results: Overall, 12% of subjects with diabetes and 17.9% of subjects without diabetes were smokers (P = 0.277). The WC, TGs, systolic and diastolic BP were significantly higher in subjects with diabetes compared to subjects without diabetes. The prevalence of high WC, high BP, low HDL, and high TGs were significantly higher in subjects with diabetes compared to subjects without diabetes. Conclusions: Cardiovascular risk factors were higher in subjects with diabetes compared to subjects without diabetes. Lifestyle intervention programs should be focused on community education about reduction of CVD risk factors in patients with diabetes.