CSF hydrothorax following V/P shunt surgery is a very rare complication that may cause serious respiratory distress. It is important to keep in mind that peritoneal catheter migration into the chest may or may not occur. Even ascites may not accompany CSF hydrothorax in a patient without peritoneal catheter migration.
Cardiac contusion is a potentially fatal complication of blunt chest trauma. The
effects of a combination of quercetin and methylprednisolone against trauma-induced
cardiac contusion were studied. Thirty-five female Sprague-Dawley rats were divided
into five groups (n=7) as follows: sham, cardiac contusion with no therapy, treated
with methylprednisolone (30 mg/kg on the first day, and 3 mg/kg on the following
days), treated with quercetin (50 mg·kg−1·day−1), and treated
with a combination of methylprednisolone and quercetin. Serum troponin I (Tn-I) and
tumor necrosis factor-alpha (TNF-α) levels and cardiac histopathological findings
were evaluated. Tn-I and TNF-α levels were elevated after contusion (P=0.001 and
P=0.001). Seven days later, Tn-I and TNF-α levels decreased in the rats treated with
methylprednisolone, quercetin, and the combination of methylprednisolone and
quercetin compared to the rats without therapy, but a statistical significance was
found only with the combination therapy (P=0.001 and P=0.011, respectively).
Histopathological degeneration and necrosis scores were statistically lower in the
methylprednisolone and quercetin combination group compared to the group treated only
with methylprednisolone (P=0.017 and P=0.007, respectively). However, only
degeneration scores were lower in the combination therapy group compared to the group
treated only with quercetin (P=0.017). Inducible nitric oxide synthase positivity
scores were decreased in all treatment groups compared to the untreated groups
(P=0.097, P=0.026, and P=0.004, respectively). We conclude that a combination of
quercetin and methylprednisolone can be used for the specific treatment of cardiac
contusion.
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