Background
Several studies have reported changes in the corpus callosum (CC) in Alzheimer’s disease. However, the involved region differed according to the study population and study group. Using deep learning technology, we ensured accurate analysis of the CC in Alzheimer’s disease.
Methods
We used the Open Access Series of Imaging Studies (OASIS) dataset to investigate changes in the CC. The individuals were divided into three groups using the Clinical Dementia Rating (CDR); 94 normal controls (NC) were not demented (NC group, CDR = 0), 56 individuals had very mild dementia (VMD group, CDR = 0.5), and 17 individuals were defined as having mild and moderate dementia (MD group, CDR = 1 or 2). Deep learning technology using a convolutional neural network organized in a U-net architecture was used to segment the CC in the midsagittal plane. Total CC length and regional magnetic resonance imaging (MRI) measurements of the CC were made.
Results
The total CC length was negatively associated with cognitive function. (beta = -0.139, p = 0.022) Among MRI measurements of the CC, the height of the anterior third (beta = 0.038, p <0.0001) and width of the body (beta = 0.077, p = 0.001) and the height (beta = 0.065, p = 0.001) and area of the splenium (beta = 0.059, p = 0.027) were associated with cognitive function. To distinguish MD from NC and VMD, the receiver operating characteristic analyses of these MRI measurements showed areas under the curves of 0.65–0.74. (total CC length = 0.705, height of the anterior third = 0.735, width of the body = 0.714, height of the splenium = 0.703, area of the splenium = 0.649).
Conclusions
Among MRI measurements, total CC length, the height of the anterior third and width of the body, and the height and area of the splenium were associated with cognitive decline. They had fair diagnostic validity in distinguishing MD from NC and VMD.
Computational methods to model political bias in social media involve several challenges due to heterogeneity, high-dimensionality, multiple modalities, and the scale of the data. Political bias in social media has been studied in multiple viewpoints like media bias, political ideology, echo chambers, and controversies using machine learning pipelines. Most of the current methods rely heavily on the manually-labeled groundtruth data for the underlying political bias prediction tasks. Limitations of such methods include human-intensive labeling, labels related to only a specific problem, and the inability to determine the near future bias state of a social media conversation. In this work, we address such problems and give machine learning approaches to study political bias in two ideologically diverse social media forums: Gab and Twitter without the availability of human-annotated data. Our proposed methods exploit the use of transcripts collected from political speeches in US congress to label the data and achieve the highest accuracy of 70.5% and 65.1% in Twitter and Gab data respectively to predict political bias. We also present a machine learning approach that combines features from cascades and text to forecast cascade's political bias with an accuracy of about 85%.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.