The subchronic effect of aqueous stem bark extract of Khaya senegalensis on some biochemical, haematological, and histopathological parameters of rats was investigated. The rats were divided into six groups of five rats per group. Groups I to VI were administered graded doses of 0, 400, 800, 1200, 1600, and 2000 mg/kg bw, respectively. The result of study revealed that administration of the Khaya senegalensis for twenty-eight days at the experimental dose resulted in significant (P < 0.05) increase in urea, electrolytes (Na+, K+), and creatinine levels. The extract also significantly (P < 0.05) increased serum activity of ALT, AST, and ALP. The levels of protein, albumin, and bilirubin were significantly changed when compared to their control values, but they were not dose dependent. The hematological indices assayed in this study were not significantly affected at the experimental dose when compared to the control values. Histological studies of the liver showed cellular degeneration and necrosis and bile duct hyperplasia and fibrosis with lymphocytic infiltration of the hepatocyte, providing supportive evidence for discussing the biochemical findings, indicative of functional derangement. The histological architecture of the kidney and that of the heart were however preserved. The result of this study indicates that the aqueous stem bark extract of K. senegalensis may affect the cellular integrity of vital organs of the body.
Neurofibroma of the scalp are mostly multiple as part of neurofibromatosis or other phakomatosis. De novo solitary types are less common and rarely erode the skull, unlike the intracranial counterpart. Skull erosion has been reported in adults with longstanding plexiform neurofibromas. We report a giant neurofibroma on the scalp of a five-year-old boy, managed in our center. Although this condition is a rare entity, it should be anticipated and the treatment strategy should include repair of the skull defect.
BackgroundThe customary puerperal practice of Natron consumption has been identified as one of the predisposing factors in the etiology of peripartum cardiomyopathy (PPCM). This study was designed to investigate the effect of Natron in postpartum Wistar albino rats.MethodsA total of 30 postpartum Wistar rats were exposed to different doses (50 mg/kg, 100 mg/kg, 200 mg/kg and 300 mg/kg) of Natron for 28 days. After the treatment, we carried out biochemical analyses and histological evaluations of kidney, liver and heart.ResultsThe study revealed that the exposure of postpartum rats to 100 mg/kg of Natron and above significantly (p < 0.05) increase the cardiac markers; myoglobin, creatine kinase-MB, troponin I and T as compared with control. The result of liver function indicated no significant difference in alanine aminotransferase, aspartate aminotransferase, gamma-glutamyltransferase, albumin and total protein of the Natron treated groups as compared with control. However, at higher doses, the levels of total protein, globulin and alkaline phosphatase activity were significantly increased in comparison to the control. There was no significant difference in the kidney function markers of the treatment groups as compared with control. Histological examinations revealed no changes in the kidney of the treated groups. Mild portal triaditis was observed in the liver of the treated rats. The heart of the rats administered ≥100 mg/kg of Natron showed myocyte hypertrophy.ConclusionThe study demonstrated that the administration of Natron for 28 days caused changes in the heart of postpartum rats and thus may contribute to the pathogenesis of PPCM.
Background: Urinary Bladder Cancer is a common disease worldwide. It ranks ninth in cancer incidence and is the 13th leading cause of cancer death among men and women worldwide. The highest incidence is seen usually in developed countries. In our environment, it is the leading cause of cancer and cancer deaths among males because of endemicity of urinary schistosomiasis. Yet, little is done to curb this preventable risk factor of bladder cancer. Objective: The objectives of this study were to describe histopathological pattern of urinary bladder cancer in Sokoto, Northwestern Nigeria. Method: This was a retrospective study of all histologically confirmed cases of bladder cancer seen at the Department of Histopathology, Usmanu Danfodiyo University Teaching Hospital, Sokoto between the years 2006 and 2015. Information was obtained from the database of the Department of Histopathology. The data were validated using Microsoft Excel and exported to SPSS for analysis. The data were analysed for age, sex and histological types using SPSS version 20 software. The results are presented in the form of simple frequency tables and percentages. Results: A total of 190 patients were seen with histologically confirmed bladder cancer out of the 3933 patients with malignancies between the years 2006 and 2015, constituting 4.8% of all malignancies diagnosed in the same period and comprises 160(84.2%) males and 30(15.8%) females with male to female ratio of 5.3:1. Their mean age was 50.8, SD ±14.9 years and range from 1-90 years. The most common bladder cancer was squamous cell carcinoma with 97 (51.1%) cases. 81 (42.6%) patients had urothelial carcinoma, 5(2.6%) were metastatic carcinoma, 4(2.1%) were sarcomatoid carcinoma, 2(1.1%) were rhabdomyosarcoma and only 1(0.5%) case of a signet ring cell carcinoma was recorded. Conclusion: Squamous cell carcinoma remained the most common histological type of bladder cancer in our setting followed by urothelial carcinoma. Preventive measures aim at eradicating urinary schistosomiasis, a predominant and known risk factor of bladder cancer in our environment will go a long way in curtailing the burden of this disease among our people. Citation Format: Saddiku Malami Sahabi, Kabiru Abdullahi. Urinary bladder cancer in Sokoto, Northwestern Nigeria: A 10-year histopathological review [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 1212.
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