The medical records of 219 epileptic patients seen over a period of eight years were reviewed to determine the incidence and causes of intractable epilepsy amongst adults in Qatar: The incidence rate of hospital admission with uncontrolled epilepsy was calculated as 25per 100,000persons. Thirty-nine patients (18%) fulfilled the criteria for IE and the incidence of IE could be approximated at 4.5 per 100,000 persons. In the native Qatari population the approximated incidence of IE would be 1 in 100,000 persons per year, while in the expatriate population the rate would be 3.5 per 100,000 persons per year. The most common type of IE was idiopathic generalized epilepsy (75%) followed by symptomatic epilepsy (19%) and temporal lobe epilepsy (6%). To calculate the crude incidence of epilepsy in Qatar, the records were reviewed of 1217patients (aged 13-85 years) visiting the outpatient department or admitted to hospital because of a newly diagnosed epilepsy during the calendar year, 1st January-31st December 2001. These figures were extrapolated to an approximation of an incidence of 174 in 100,000 persons per year.
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Atherosclerosis is a systemic pathologic process, may involve aorta and is important cause of systemic embolization. The risk of embolism is increased for mobile and complex aortic plaques that are >4 mm thick. The most common manifestations are stroke, transient ischemic attack (TIA) and peripheral embolization. Imaging modalities used include transesophageal echocardiogram (TEE), CT angiography and magnetic resonance angiography (MRA). The mainstays of medical treatment are antiplatelets and statin. The role of anticoagulation is reserved for plaques with thrombotic component. There were two patients who presented with large acute ischemic stroke with high grade, floating aortic arch thrombus and complex aortic arch plaques. In one of cases, after 10-day follow-up CT aortic angiography showed completely resolved thrombus after being treated with IV tissue plasminogen activator (TPA) followed by low molecular weight heparin (LMWH). The risk of embolism depends on size of aortic plaques and mobility. TEE is modality of choice for thoracic aortic plaques. Aortic plaques >4 mm are independent predictors of recurrent ischemic stroke. There are limited data available for off-label use of intravenous thrombolysis and mechanical thrombectomy (MT) in presence of aortic arch thrombus in acute ischemic strokes. These two case reports help in recognition of aortic arch complex plaques as independent risk factor for recurrent stroke. The right patients may consider about the use of intravenous alteplase and MT performed via trans-brachial access after excluding aortic dissection and aneurysm. In future, multicenter, randomized controlled trials will be required for safety of IV TPA and MT.
1.7% of myeloproliferative neoplasms are associated with autoimmune conditions. Association of myasthenia gravis (MG) with chronic myeloid leukemia is reported, but its association with polycythemia vera (PV) has never been reported. We report two patients who had MG and PV with JAK2V617F mutation. Both had splenomegaly but no thymoma.
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