Background: Percutaneous closure of atrial septal defect (ASD) has replaced surgical ASD closure for anatomically suitable ASD. Complication rate of percutaneous procedure is relatively less when compared to surgical closure of ASD. Thromboembolic events leading onto stroke during the procedure is considered extremely rare. Case Report: A 10 year old female who underwent percutaneous ASD device closure had peri-procedure stroke. Cerebral angiogram confirmed acute right middle cerebral artery (MCA) thrombosis. A microcatheter was inserted into occluded MCA, thrombus was disrupted and flow was established. Patient recovered post-procedure. Conclusion: Procedure related thromboembolism is very rare but not unheard of. As there is no consensus on acute procedure related stroke in pediatric population, newer therapeutic explorations may be helpful alternatives.
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