A simple rapid spectrophotometric method has been developed for estimation of cefuroxime axetil from bulk drug and tablet dosage form by using 1-nitroso-2-napthol and sodium hydroxide. The method is based on the formation of yellow-orange coloured complex of drug with 1-nitroso-2-napthol having absorbance maxima at 424 nm. The Beer’s law is obeyed in the concentration range of 10-50 μg/ml of the drug but more precisely it obeys in the range of 10- 30 μg/ml. The slope and intercept values are 0.0101 and 0.0838, respectively. Results of analysis of this method were validated statistically and by recovery studies. The method is applied to the marketed tablet formulation. Result of analysis of tablet formulation given as percentage of label claim ±standard deviation is 99.17±1.57. The precision and accuracy was examined by performing recovery studies and was found to be 99.50±1.82. Sandell’s correlation coefficient is calculated as 0.4434. The developed method is simple, sensitive and reproducible and can be used for routine analysis of cefuroxime axetil from bulk and tablet dosage form.
An attempt has been made to develop an economic, sensitive and reproducible colorimetric method for quantitative estimation of Aceclofenac from bulk drug and in pharmaceutical formulations. The first method employs Ferric chloride reagent in presence of hydrochloric acid and Potassium ferricyanide to form greenish complex with Aceclofenac. The concentration of Aceclofenac over a range of 10-60 µg/ml was found sufficient for obeying Beer's law in the stated range. The second method employs Ferric ammonium sulphate reagent in presence of hydrochloric acid and Potassium ferricyanide to form greenish complex with Aceclofenac. The concentration of Aceclofenac over a range of 10-50 µg/ml was found sufficient for obeying Beer's law in the stated range. The drug was determined in the presence of tablet excipients, concentration range in first method of 10-60 ug ml-1 and mean recoveries are 99.92 ± 0.16 and 100.88 ± 0.55 and concentration range in second method of 10-50 ug ml-1 and mean recoveries are 100.79 ± 0.087 and 99.36 ± 0.23 respectively for two formulations. Simplicity, ease of operation and short time required for analysis makes the method useful for routine analysis of Aceclofenac in bulk as well as in tablet formulation.
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