Background. Full-thickness cartilage lesions of the patella represent a common source of pain and dysfunction. Previously reported surgical treatment options include marrow stimulation, cell-based treatments, and osteochondral transfer. Minced juvenile allograft cartilage is a novel treatment option that allows for a single stage approach for these lesions. Hypothesis. Particulated juvenile allograft cartilage (PJAC) for the treatment of chondral defects of the patella would offer acceptable lesion fill rates, mature over time, and not be associated with any negative biologic effects on the surrounding tissue. Methods. A retrospective chart review of prospectively collected data was conducted to identify consecutive patients who were treated with PJAC for a full thickness symptomatic cartilage lesion. Qualitative (fast spin echo) and quantitative (T2 mapping) magnetic resonance imaging (MRI) was undertaken at the 6-, 12-, and 24-month postoperative mark. Numerous patient, lesion, and graft specific factors were assessed against MRI scores and percent defect fill of the graft. Graft maturation over time was also assessed. Results. Forty-five patients total were included in the study. Average age at the time of surgery was 26.5 years (range 13-45 years), average lesion size was 208 mm 2 (range 4-500 mm 2 ), and average donor age was 49.5 months (range 3-120 months). Sixty percent of the patients were female, while 93% of all patients underwent a concomitant procedure at the time of the index operation. Six-month MRI findings revealed that no patient-, graft-, or donor-specific factors correlated with MR scores, and 82% of the knees demonstrated good to excellent fill. Twelve-month MRI findings revealed that T2 relaxation times of deep graft demonstrated negative correlation with patient age (P = 0.049) and donor age (P = 0.006), the integration zone showed a negative correlation with donor age (P = 0.026). In all, 85% of patients at 12 months displayed good to moderate fill of the graft. At 24 months, patient age demonstrated negative correlation with average T2 relaxation times of the deep and superficial graft (P = 0.005; P = 0.0029) and positive correlation with the superficial zone of the adjacent cartilage (P = 0.001). Donor age showed negative correlation with grayscale score (P = 0.004) and T2 relaxation times at deep integration zone (P = 0.018). T2 relaxation times of deep and superficial graft and integration zone improved over time (P < 0.001) and between each time point.Conclusions. Particulated juvenile allograft tissue appears to be an acceptable reconstructive option for full-thickness cartilage lesions of the patella, offering satisfactory tissue defect fill at 6, 12, and 24 months after surgery. Imaging of the repaired cartilage demonstrates progressive graft maturation over time.
Osteoarthritis (OA) in the knee is common, painful, and may be uni- or multicompartmental. The compartment affected by arthritis may be due to trauma, malalignment (varus or valgus), or in the case of patellofemoral OA, patella alta. Patellofemoral arthroplasty (PFA) is an effective partial knee replacement surgery for patellofemoral OA. We hypothesized that PFA can decrease patellar height. In addition, we predicted better outcomes for patients with patella alta before PFA and those whose patellar heights decreased after PFA. This is a retrospective cohort study of PFA patients from 2012 to 2020. Before and after PFA, we measured patellar heights on X-ray images and collected patient-reported outcome measures (PROMs) (International Knee Documentation Committee score, Kujala Anterior Knee Pain Score, and Veterans RAND 12-Item Health Survey for mental and physical health). Statistical analyses assessed PROMs and compared outcomes based on pre- and postoperative patella height. Of 133 knees, 73% presented with patella alta and 61% had patellar heights that decreased after PFA. Compared with patients who did not present with patella alta, patients with patella alta reported similar outcomes with respect to knee function, pain, and general physical and mental health. Compared with patients whose patellar heights decreased after PFA, patients whose knees did not decrease in height reported greater improvements in pain and function. Our findings suggest that patella alta is commonly found in patients with patellofemoral OA and that PFA can decrease patellar height. Future studies are needed to assess whether patellofemoral OA patients with greater degrees of patella alta would benefit from staged or concurrent tibial tubercle distalization.
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