Syntheses for a set of new ligands containing one or two carbamoylmethylphosphine oxide (CMPO) fragments appended to pyridine and pyridine N-oxide platforms are described. Molecular mechanics analyses for gas phase lanthanide-ligand interactions for the pyridine N-oxides indicate that the trifunctional NOPOCO molecules, 2-{[Ph2P(O)][C(O)NEt2]C(H)}C5H4NO (7) and 2-{[Ph2P(O)][C(O)NEt2]CHCH2}C5H4NO (8), and pentafunctional NOPOP'O'COC'O' molecules, 2,6-{[Ph2P(O)][C(O)NEt2]C(H)}2C5H3NO (9) and 2,6-{[Ph2P(O)][C(O)NEt2]CHCH2}2C5H3NO (10), should be able to adopt, with minimal strain, tridentate and pentadentate chelate structures, respectively. As a test of these predictions, selected lanthanide coordination chemistry of the N-oxide derivatives was explored. Crystal structure analyses reveal the formation of a tridentate NOPOCO chelate structure for a 1:1 Pr(III) complex containing 7 while 8 adopts a mixed bidentate/bridging monodentate POCO/NO binding mode with Pr(III). Tridentate and tetradentate chelate structures are obtained for several 1:1 complexes of 9 while a pentadentate chelate structure is observed with 10. Emission spectroscopy for one complex, [Eu(9)(NO3)3], in methanol, shows that the Eu(III) ion resides in a low-symmetry site. Lifetime measurements for methanol and deuterated methanol solutions indicate the presence of four methanol molecules in the inner coordination sphere of the metal ion, in addition to the ligand, with the nitrate anions most likely dissociated. The solvent extraction performance of 7-10 in 1,2-dichloroethane for Eu(III) and Am(III) in nitric acid solutions was analyzed and compared with the performance of 2,6-bis(di-n-octylphosphinoylmethyl)pyridine N-oxide (TONOPOP'O') and n-octyl(phenyl)-N,N-diisobutylcarbamoylmethylphosphine oxide (OPhDiBCMPO) measured under identical conditions.

Stepwise syntheses of 2-{[2-(diphenylphosphoryl)acetamido]methyl}pyridine 1-oxide, 2-[Ph2P(O)CH2C(O)N(H)CH2]C5H4NO (6), 2-{[2-(diphenylphosphoryl)acetamido]methyl}-6-[(diphenylphosphoryl)methyl]pyridine 1-oxide, 2-[Ph2P(O)CH2C(O)N(H)CH2]-6-[Ph2P(O)CH2]C5H3NO (7) and 2,6-bis{[2-(diphenylphosphoryl)acetamido]methyl}pyridine 1-oxide, 2,6-[Ph2P(O)CH2C(O)N(H)CH2]2C5H3NO (8), are reported along with spectroscopic characterization data and single crystal X-ray diffraction structure determination for 6·2H2O, 7 and 2,6-[Ph2P(O)CH2C(O)N(H)CH2]2C5H3N·MeOH 18·MeOH, the pyridine precursor of 8. Molecular mechanics computations indicate that 6, 7 and 8 should experience minimal steric hindrance to donor group reorganization that would permit tridentate, tetradentate and pentadentate docking structures for the respective ligands on lanthanide cations. However, crystal structure determination for the lanthanide complexes, {[Yb(6)(NO3)3]·(MeOH)}n, {[Lu(6)(NO3)3]·(MeOH)}n, [Er(6)2(H2O)2](NO3)3·(H2O)4}n, {[La(13)(NO3)3(MeOH)]·(MeOH)}n, {[Eu(7)(NO3)2(EtOAc)0.5(H2O)0.5](NO3)}2·MeOH and [Dy3(7)4(NO3)4(H2O)2](NO3)5·(MeOH)5·(H2O)2 reveal solid-state structures with mixed chelating/bridging ligand : Ln(III) interactions that employ lower than the maximal denticity. The binding of 6 and 7 with Eu(III) in the solid state and in MeOH solutions is also accessed by emission spectroscopy. The acid dependence for solvent extractions with 6 and 7 in 1,2-dichloroethane for Eu(III) and Am(III) in nitric acid solutions is described and compared with the behavior of n-octyl(phenyl)-N,N-diisobutylcarbamoylmethylphosphine oxide (OPhDiBCMPO, 1b) and 2-[(diphenyl)phosphinoylmethyl]pyridine N-oxide (DPhNOPO, 4a).

Syntheses for new ligands based upon dibenzothiophene and dibenzothiophene sulfone platforms, decorated with phosphine oxide and methylphosphine oxide donor groups, are described. Coordination chemistry of 4,6-bis(diphenylphosphinoylmethyl)dibenzothiophene (8), 4,6-bis(diphenylphosphinoylmethyl)dibenzothiophene-5,5-dioxide (9) and 4,6-bis(diphenylphosphinoyl)dibenzothiophene-5,5-dioxide (10) with lanthanide nitrates, Ln(NO3)3·(H2O)n is outlined, and crystal structure determinations reveal a range of chelation interactions on Ln(III) ions. The nitric acid dependence of the solvent extraction performance of 9 and 10 in 1,2-dichloroethane for Eu(III) and Am(III) is described and compared against the extraction behavior of related dibenzofuran ligands (2, 3; R = Ph) and n-octyl(phenyl)-N,N-diisobutylcarbamoylmethyl phosphine oxide (4) measured under identical conditions.

Stereoselective cyclization of zincated α-N-homoallylamino nitriles has been developed. Following treatment with lithium diisopropylamide (LDA) and transmetalation with zinc bromide, α-N-(1-phenylethyl)-N-homoallylamino nitriles lead to 2,3-methanopyrrolidines in moderate to good yields (up to 66 %) and excellent selectivities (up to >98:2). With substrates derived from α-branched homoallylic amines, a stereospecific inversion of the homoallylic stereogenic center was observed. To account for this, a mechanistic rationale involving the formation of zincioiminium ions from zincated α-amino nitriles is put forward. 2,3-Methanopyrrolidines should then arise from a sequence involving an aza-Cope rearrangement providing a configurationally stable (2-azoniaallyl)zinc species that then undergoes a [3+2] cycloaddition reaction.

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Efficient syntheses for the precursor molecules, 2‐{6‐[((diphenylphosphoryl)methyl)pyridin‐2‐yl]methyl}isoindoline‐1,3‐dione (2), 2‐[(1,3‐dioxoisoindolin‐2‐yl)methyl]‐6‐[(diphenylphosphoryl)methyl]pyridine 1‐oxide (3), and their 6‐[bis(2‐(trifluoromethyl)phenyl)phosphoryl]methyl analogues are reported along with their transformations into the dissymmetric ligands, [(6‐(aminomethyl)pyridin‐2‐yl)methyl]diphenylphosphine oxide (4), 2‐(aminomethyl)‐6‐[(diphenylphosphoryl)methyl]pyridine 1‐oxide (5) and 2‐(aminomethyl)‐6‐{[bis(2‐(trifluoromethyl)phenyl)phosphoryl]methyl}pyridine 1‐oxide (5‐F). Selected reactivity of the aminomethyl substituent of 4 and 5, as well as complexation reactions of several of the compounds with lanthanide(III) ions are described. Molecular structures of three uniquely different complexes, {Pr{2‐[HC(O)N(H)CH2]‐6‐[Ph2P(O)CH2]C5H3NO}(NO3)3(MeOH)}2, {Eu{2‐[(Me2N)2CN(H+)CH2]‐6‐[Ph2P(O)CH2]C5H3N(H)+}(NO3)4(OMe)} and {Er{2‐[(C8H4O2)NCH2]‐6‐[Ph2P(O)CH2]C5H3N(O)}(NO3)3(MeOH)}·(CH3)2CO, have been determined by single‐crystal X‐ray diffraction methods. The observed and computationally modeled structures that employ bidentate and tridentate ligand/metal interactions are compared. These results suggest further ligand modifications that should provide improved solvent extraction reagents.

Synthesis and selected lanthanide coordination chemistry of new ((1H-pyrazol-1-yl)methyl)pyridine and -pyridine 1-oxide ligands, Polyhedron (2015), doi: http://dx. ABSTRACTSyntheses for new potentially chelating ligands, 2,6-bis((1H-pyrazol-1-yl)methyl)pyridine 1-oxide (2), (4) and 2-((1H-pyrazol-1-yl)methyl)-6-((diphenylphosphoryl)methyl)pyridine 1-oxide (5), that are based upon pyridine or pyridine N-oxide platforms functionalized with pyrazol-1-ylmethyl and diphenylphosphinoylmethyl substituents, are reported along with results from molecular modeling analyses that assess the strain energy encountered by the ligands in tridentate chelate interactions for gas phase [Eu(L) 3+ ]complexes.Coordination chemistry with selected lanthanide nitrates is described along with X-ray crystal structure determinations for the three ligands and three representative coordination complexes.