Little is still known about the neuroanatomical substrates related to changes in specific cognitive abilities in the course of healthy aging, and the existing evidence is predominantly based on cross-sectional studies. However, to understand the intricate dynamics between developmental changes in brain structure and changes in cognitive ability, longitudinal studies are needed. In the present article, we review the current longitudinal evidence on correlated changes between magnetic resonance imaging-derived measures of brain structure (e.g. gray matter/white matter volume, cortical thickness), and laboratory-based measures of fluid cognitive ability (e.g. intelligence, memory, processing speed) in healthy older adults. To theoretically embed the discussion, we refer to the revised Scaffolding Theory of Aging and Cognition. We found 31 eligible articles, with sample sizes ranging from n = 25 to n = 731 (median n = 104), and participant age ranging from 19 to 103. Several of these studies report positive correlated changes for specific regions and specific cognitive abilities (e.g. between structures of the medial temporal lobe and episodic memory). However, the number of studies presenting converging evidence is small, and the large methodological variability between studies precludes general conclusions. Methodological and theoretical limitations are discussed. Clearly, more empirical evidence is needed to advance the field. Therefore, we provide guidance for future researchers by presenting ideas to stimulate theory and methods for development.

Cognitive training interventions have become increasingly popular as a potential means to cost-efficiently stabilize or enhance cognitive functioning across the lifespan. Large training improvements have been consistently reported on the group level, with, however, large differences on the individual level. Identifying the factors contributing to these individual differences could allow for developing individually tailored interventions to boost training gains. In this study, we therefore examined a range of individual differences variables that had been discussed in the literature to potentially predict training performance. To estimate and predict individual differences in the training trajectories, we applied Latent Growth Curve models to existing data from three working memory training interventions with younger and older adults. However, we found that individual differences in demographic variables, real-world cognition, motivation, cognitionrelated beliefs, personality, leisure activities, and computer literacy and training experience were largely unrelated to change in training performance. Solely baseline cognitive performance was substantially related to change in training performance and particularly so in young adults, with individuals with higher baseline performance showing the largest gains. Thus, our results conform to magnification accounts of cognitive change.Keywords Working memory training . Individual differences . Latent growth curve modeling Over the past decade, there has been an exploding interest in computer-based commercial Bbrain training^programs and in scientific evidence relating to the effectiveness of such interventions, triggered by promising results of working memory (WM) training gains generalizing to previously untrained cognitive abilities such as intelligence in both younger (e.g., Jaeggi et al. 2008) and older adults (e.g., Borella et al. 2010). Although the idea of improving general cognitive functioning within a few weeks is enticing, there is also accumulating evidence against a generalized effect of WM training (e.g., Clark et al. 2017;De Simoni and von Bastian 2017;Guye and von Bastian 2017;Sprenger et al. 2013). Even on the meta-analytic level, evidence is mixed regarding the effectiveness of cognitive training in both younger and older adults (e.g., Au et al. 2015;Dougherty et al. 2016;Karbach and Verhaeghen 2014;Kelly et al. 2014;Lampit et al. 2014;Melby-Lervåg and Hulme 2013;Melby-Lervåg et al. 2016;Schwaighofer et al. 2015;Soveri et al. 2017). Aside from design and methodological choices potentially explaining the diverging findings (e.g., Noack et al. 2009;Shipstead et al. 2012), many authors increasingly articulated the potentially important influence of individual differences on cognitive training trajectories and outcomes (e.g., Buitenweg et al. 2012;Guye et al. 2016;Könen and Karbach 2015;Shah et al. 2012;von Bastian and Oberauer 2014 Individual differences in cognitive functioning (e.g., Ackerman and Lohman 2006) and learning potential (e.g., Stern ...

The question of whether working memory training leads to generalized improvements in untrained cognitive abilities is a longstanding and heatedly debated one. Previous research provides mostly ambiguous evidence regarding the presence or absence of transfer effects in older adults. Thus, to draw decisive conclusions regarding the effectiveness of working memory training interventions, methodologically sound studies with larger sample sizes are needed. In this study, we investigated whether or not a computer-based working memory training intervention induced near and far transfer in a large sample of 142 healthy older adults (65-80 years). Therefore, we randomly assigned participants to either the experimental group, which completed 25 sessions of adaptive, process-based working memory training, or to the active, adaptive visual search control group. Bayesian linear mixed-effects models were used to estimate performance improvements on the level of abilities, using multiple indicator tasks for near (working memory) and far transfer (fluid intelligence, shifting, and inhibition). Our data provided consistent evidence supporting the absence of near transfer to untrained working memory tasks and the absence of far transfer effects to all of the assessed abilities. Our results suggest that working memory training is not an effective way to improve general cognitive functioning in old age.

Virtual Coaches, also known as e-coaches, are a disruptive technology in healthcare. Indeed, among other usages, they might provide cost-effective solutions for increasing human wellbeing in different domains, such as physical, nutritional, cognitive, social, and emotional. This paper presents a systematic review of virtual coaches specifically aimed at improving or maintaining older adults' health in the aforementioned domains. Such digital systems assume various forms, from classic apps, to more advanced conversational agents or robots. Fifty-six articles describing a virtual coach for older adults and aimed at improving their wellbeing were identified and further analyzed. In particular, we presented how previous studies defined their virtual coaches, which behavioral change models and techniques they adopted and the overall system architecture, in terms of monitoring solutions, processing methods and modalities for intervention delivery. Our results show that few thorough evaluations of e-coaching systems have been conducted, especially regarding multi-domain coaching approaches. Through our analysis, we identified the wellbeing domains that should be addressed in future studies as well as the most promising behavior change models and techniques and coaching interfaces. Previous work illustrates that older adults often appreciate conversational agents and robots. However, the lack of a multidomain intervention approach in the current literature motivates us to seek to define future solutions.

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In the context of the fourth revolution in healthcare technologies, leveraging monitoring and personalization across different domains becomes a key factor for providing useful services to maintain and promote well-being. This is even more crucial for older people, with aging being a complex multi-dimensional and multi-factorial process which can lead to frailty. The NESTORE project was recently funded by the EU Commission with the aim of supporting healthy older people to sustain their well-being and capacity to live independently. It is based on a multi-dimensional model of the healthy aging process that covers physical activity, nutrition, cognition, and social activity. NESTORE is based on the paradigm of the human-in-the-loop cyber-physical system that, exploiting the availability of Internet of Things technologies combined with analytics in the cloud, provides a virtual coaching system to support healthy aging. This work describes the design of the NESTORE methodology and its IoT architecture. We first model the end-user under several domains, then we present the NESTORE system that, analyzing relevant key-markers, provides coaching activities and personalized feedback to the user. Finally, we describe the validation strategy to assess the effectiveness of NESTORE as a coaching platform for healthy aging.

This chapter argues that the question of whether working memory training can induce cognitive plasticity in terms of transfer effects cannot be conclusively answered yet due to persisting methodological issues across the literature. The shortcomings discussed include the lack of theoretically motivated selection of training and transfer tasks, the lack of active control groups, and small sample sizes. These problems call into question the strength of the existing evidence. Indeed, reevaluating published findings with Bayesian inference indicated that only a subset of published studies contributed interpretable evidence. The chapter concludes that the current body of literature cannot conclusively support claims that WM training does or does not improve cognitive abilities and stresses the need for theory-driven, methodologically sound studies with larger sample sizes.

5. Zeltser DW, Strauch RJ. Vascular anatomy relevant to distal biceps tendon repair.