Objectives
Compressibility of materials is determining the tableting behaviour and tablet properties during and after manufacturing. The compressibility constant has not been investigated as an in-die method yet and was therefore compared with the Heckel analysis for describing the compressibility of materials during tableting in this study.
Methods
Various parameters influencing tableting, such as compression pressure, compression speed and punch diameter, were used to analyze the robustness of both methods and to evaluate the informative value of the compression parameters. Twelve common pharmaceutical excipients were used to cover a wide range of material properties.
Key findings
The compressibility constant was successfully applied as an in-die method and proved to be more robust against the influencing parameters during tableting than the Heckel analysis. A good correlation between the out-of-die and in-die method was found for both methods but could not be observed between the compressibility constant and the yield pressure from Heckel analysis. The methods are both describing the volume reduction of materials under pressure but focus on different material properties.
Conclusions
For material characterization in the field of tableting, the compressibility constant can be additionally applied in the future to be able to determine another compressibility parameter in combination with the yield pressure.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.