Background: Fibromyalgia (FM) is a chronic musculoskeletal disorder resulting in chronic widespread pain. Although it is currently believed to be the result of a central nervous system malfunction that increases pain transmission and perception. Patients with fibromyalgia frequently experience psychiatric problems. Objectives: Is to estimate the presence of fibromyalgia among Egyptian patients with rheumatoid arthritis (RA) and those with chronic depression. Patients and methods: This study was done on 277 patients; 176 patients with rheumatoid arthritis (group I), and 101 patients with chronic depression (group II). The patients were selected from Al-Zahraa University Hospital, Al-Azhar University. All patients were subjected to thorough clinical examination, laboratory investigation, calculation of disease activity score, modified Beck scale for depression. Results: Among RA patients FM diagnosis was established in 21.02% patients and 20.45% were females. Their mean age; 48.43 (±6.85) years that was significantly higher than RA patients only (29.48±8.59) years. Among (group II) patients, FM diagnosis was established in 40 (39.60%) female patients and 3(2.97%) male patients. Our results showed that depressive symptoms were more common in RA patients with fibromyalgia. DAS28 score was significantly higher in RA patients with FM mainly due to subjective component (number of tender joints and patient global assessment). Conclusion: Fibromyalgia may coexist with autoimmune inflammatory disorder like RA, commoner in older age, females and it worsens the disease activity. However, it is more common in patients with chronic depression.
Background: Rheumatoid arthritis is a systemic inflammatory disease that can involve other tissues and organs as well as synovial joints. It is characterized by destructive polyarthritis and extra-articular organ involvement, including skin, eye, heart, lung, renal, central and peripheral nervous system and gastrointestinal tract. The extra-articular manifestations of RA can occur at any age. Objectives of this study are to evaluate extra articular manifestations in Egyptian rheumatoid arthritis patients, its relation to the disease activity score (DAS28) and Anti-Cyclic Citrullinated Peptide (ACPA). Methods: This study was conducted on 50 patients they were diagnosed as RA by fulfilling the American College of Rheumatology (ACR) criteria of RA. Their age (mean±SD) is 45.78±13.26 years. Forty four (88%) of them were females, 6 (12%) were males. They were subjected to full medical history and examination, laboratory investigations were done, calculation of DAS28 score, measurement of plasma Anti-Cyclic Citrullinated Peptide (ACPA). RA patients were classified according to DAS 28 into three groups. Results: RA group 1 (mild disease activity) includes 12 (24%) patients with mean±SD of DAS 28 was 2.5±0.55, group II (moderate disease activity) includes 28 (56%) patients with mean±SD of DAS 28 was 3.9±0.55 and group III (severe disease activity) includes 10 (20%) patients with mean±SD of DAS 28 was 5.35±0.238. There was highly significant increase in mean±SD of ACPA titer in group III (sever activity), 90.31±40.78 IU/ml than that of group II 56.48±27.62 IU/ml, (p=0.000) and group1; 36.74±18.95 IU /ml also mean ACPA in group II increased significantly than that of group I, (P=0.000). Fifty (100%) RA patients had extra articular manifestations (ExRA); 37 (74%) had respiratory system disorders, 35 (70%) had hematological manifestations. CVS manifestations were found in 23 (46%). Eye manifestations present in 23 (46%) RA patients. Twelve (24%) RA patients had skin manifestations. GIT manifestations occur in 11 (22%) patients, 5 (10%) RA patients had renal manifestations. Four (8%) RA patients had neurological manifestations. The most common ExRA respiratory disorders was found in 8/12 (66.6%) patients in group I while it affect 22/28 (78.5%) patients in group II and 7/10 (70%) patients in group III (P = 0.000) with highly significant changes. Conclusion: This study showed that the ExRA are a common feature in Egyptian RA patients and they are related to the disease activity. [Egypt J Rheumatology & Clinical Immunology, 2014; 2(1): 71-79]
No abstract
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.