Objective: To assess highly sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6) as inflammatory biomarkers in patients with asymptomatic primary hyperparathyroidism (PHPT). Materials and Methods: A total of 26 patients with asymptomatic PHPT and 22 age- and sex-matched individuals as a control group were recruited for the study. Corrected serum calcium, phosphorus, alkaline phosphatase, serum 25-hydroxyvitamin D, intact parathyroid hormone (PTH), hs-CRP and IL-6 were measured for all subjects. Results: Serum hs-CRP and IL-6 were significantly higher in asymptomatic PHPT patients than in the control group (hs-CRP: 4.15 ± 0.54 vs. 2.24 ± 0.11 mg/l; IL-6: 4.50 ± 0.80 vs. 2.56± 0.29 pg/ml; p < 0.001). Moreover, in asymptomatic PHPT patients, serum PTH was significantly correlated with hs-CRP and IL-6 (r = 0.820, p < 0.001 and r = 0.787, p < 0.001, respectively). Conclusion: Inflammatory biomarkers were higher in patients with asymptomatic PHPT than in controls. Moreover, serum PTH was significantly correlated with inflammatory biomarkers which may suggest a subclinical inflammatory response in this group of patients.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.