Acinetobacter species are important opportunistic and nosocomial pathogens capable of causing both community and health careassociated infections (HAIs). The clinical specimens obtained from patients admitted in Holy Family Red Crescent Medical College and Hospital (HFRCMCH) from July 2013 to June 2015. All laboratory works were performed in department of microbiology and immunology of HFRCMCH. The infection rate was maximum in blood (67.7%) followed by urine (12.9%), tracheal aspirate (8.8%) and wound swab (3.32%). Most of the Acinetobacter were isolated from Intensive care unit (ICU) and Neonatal intensive care unit ( NICU). Acinetobacter displayed higher resistance to many antibiotics like Ampicillin which showed 96% resistance, Ceftriaxone 72%, Amikacin 72%, Imipenem 55%, Meropenem 60%, Tetraclycline 64%, Ciprofloxacin 60% and Cotrimoxazole showed 38% resistance. In conclusion, there was a high resistant rate to available and common antibiotics. It seems that infection control strategies may help to control the evolving problem of Acinetobacter infections and prevent an epidemic nosocomial life threatening infections.Bangladesh J Med Microbiol 2016; 10 (1): 18-21
Enteric fever is still an important public health problem in many developing countries like Bangladesh. A changing antibiotic susceptibility pattern of Salmonella typhi and Salmonella paratyphi A and emergence of multidrug resistance has increased to a greater concern. The present study was undertaken to find out the rate of isolation of Salmonella from Blood samples and to compare the changing patterns of drug resistance at Holy Family Hospital and Medical College and Hospital over a two year study period from January 2013 to December 2014. During the period January 2013 to December 2013, total 31 Salmonella were isolated (14% of blood isolates) in which Salmonella typhi were 27 and Salmonella paratyphi were 4. Again, during the period January 2014 to December 2014, total 27 Salmonella were isolated (10% of blood isolates) in which Salmonella typhi were 23 and Salmonella paratyphi were 4. The rate of isolation of S. typhi was noted higher among pediatric group when compared to adult group in both study periods. The sensitivity of cotrimoxazole and chloramphenicol was increased which were (80-88)% & (79-93)% respectively in 2 year study period. Nalidixic acid resistant Salmonella typhi(NARST) was 88-89% and all of NARST showing good sensitivity to ciprofloxacin. In our study period, Azythromycin resistance rate is increasing from 30-35%. All the isolates were fully susceptible to 3rd generation of cephalosporin in both study periods. The rate of Multi drug resistant(MDR) was (6.5-7.4)%; which was low in 2 year period. The policy of empirical treatment of enteric fever needs to be rationalized and newer generation antibiotics should be restricted only for multi-resistant cases of enteric fever.
This study was carried out to determine the presence of resistance gene intl1 in E. coli isolated from surgical site wound infection in Holy Family Red Crescent Medical College Hospital. A total of 90 samples were collected from the different wound sites of patients admitted in surgical ward. The most predominant organism was E. coli 48(53.33%); followed by S. aureus 23(25.56%) and Pseudomonas 12(13.33%). Most of the isolated strains of E. coli were multidrug resistant. 46(96%) strains were shown resistant to ampicillin and most potent drug against E. coli was found to be imepenem. The extended spectrum Beta-lactamase (ESBL) producing E. coli were 21(43.75%).The resistance gene marker intl1 was detected in 32(67%) E. coli isolates.DOI: http://dx.doi.org/10.3329/bjmm.v4i2.10827
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