Glucose infused to the parturient with a small-for-date fetus passes readily through the placental barrier and is retained and utilized by the fetus. The umbilical blood glucose levels are significantly increased, the arteriovenous differences show a greater retention and the FFA levels decrease. There are no signs of deterioration of fetal metabolic situation.In the small-for-date newborn the prenatal glucose infusion prevents neonatal hypoglycaemia and the enhanced FFA mobilization. Also this time metabolic changes in the newborn do not increase acidosis.The prenatal glucose infusion at a speed of 1 g glucose/min appears to be a useful tool in the treatment of small-for-date fetuses.
Changes of total blood sugars, glucose, fructose, lactate, pyruvate, acid-base balance and free fatty acids were followed in 15 healthy newborns whose mothers received fructose infusions during labour. The results were compared with 20 control newborns and with 10 newborns after prenatal glucose infusions. The levels of total blood sugars during 24 h after infusions remained higher after fructose than in 2 other groups. The values of lactate and pyruvate increased, but the lactate/pyruvate ratio remained unchanged. The free fatty acids were lower than in the control group. Results show that fructose is not a suitable source of energy for the human fetus even under normal conditions.
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