The ratio of disc to macula/disc diameter is characteristically increased in eyes with optic nerve hypoplasia. We present the largest reported series of patients with a definitive diagnosis of optic nerve hypoplasia for whom this ratio has been determined. Ali measurements were made by an independent masked observer. Our Underdevelopment of one or both optic nerves is a common anomaly.' The aetiology is unknown. Optic nerve hypoplasia (ONH) is a diagnosis which should be considered in any person with poor vision for which there is no immediately apparent explanation. Although the small optic disc of ONH is easily detected in severe cases, more subtle forms of the disorder may present more difficulty. The differential diagnosis includes the apparently small optic nerve head of hypermetropia. Subtle forms of the disorder may be difficult to distinguish from normal appearances. Red-free fundus photography can aid in this differentiation by detecting evidence of nerve fibre layer defects which correspond with that of the pattern of visual field loss.2 However, many cases of ONH do not show such focal defects and are manifest solely as a uniformly thin nerve fibre layer within affected areas, which makes the condition more difficult to define than focal defects.3Franceschetti and Bock4 measured the optic disc diameter by means of focal illumination of the fundus, using contact lens biomicroscopy and a micrometer scale. Estimation of the size of the optic disc by comparing the slit beam width on the Hagg-Streit 900 slit-lamp with the optic disc diameter on contact lens biomicroscopy has also been advocated.5 These relative measurements are useful in comparing the diameter of the optic disc relative to the slit-lamp beam or the scale, because their magnification when projected on the optic disc is assumed to be the same as the magnification of the optic disc, as the slit beam and microscope optics are parfocal and both pass through the optical system of the eye.Other methods which have been described include comparison of the size of the optic disc with the size of the whole area of the fundus as seen in the standard fundus photograph,' measurement with a scale over the frontal lens during indirect ophthalmoscopy,7 direct measurements of the orbital part of the optic nerve by CT scanning,8 A-scan ultrasonography,8 and B-scan ultrasonography.9Variations in the size of the eye with concomitant differences in dioptric power even in emmetropic eyes render absolute measurement of intraocular structures difficult.'0" Interference fringes provide a means of accurate measurement' but necessitate sophisticated equipment and a co-operative patient. The alternative is to make relative measurements from fundus photographs. The apparent size of the optic disc in fundus photographs is influenced by several factors, including the axial length, corneal curvature, and the shape of the fundus,"3 and by refractive errors and optical aberrations, but because all photographed structures are equally influenced by anatomical and re...
Pit marks and cracks in the axial region of the optic of intraocular implants (IOL) in the pseudophakic eye are a frequent clinical observation and follow Nd:YAG laser posterior capsulotomy procedures. A new technique is presented for carrying out YAG capsulotomy without risking damage to the axial part of the optic. This technique has been used successfully on 200 eyes. It makes use of the fact that an opacified posterior capsule reacts to disruption by retracting. This treatment strategy simply directs this process of retraction to create a 3 mm gap in the axial region without having to treat this area.
Optic nerve hypoplasia (ONH) is associated with a wide range of neurological and endocrine disorders. A series of 21 patients is reported. This comprised 17 with ONH in association with manifest neurological and endocrine disturbance, 3 who were blind but who were otherwise normal, and 1 with bilateral impaired visual acuity only. AH patients underwent neuroradiological and detailed ophthalmic assessment. A wide range of abnormalities was observed. The most common findings were absent septum pel lucid urn, hydrocephaly, and porencephaly. Evidence of hypothalamic/pituitary hormone deficiency was present in nine patients, six of whom had demonstrable intracranial radiological abnormalities. All patients except one had bilateral optic nerve hypoplasia. Most patients had poor visual acuities and nystagmus. Astigmatism was also common. Two conditions which have not previously been reported in association with optic nerve hypoplasia were found: an intracranial arachnoid cyst and an intracranial epidermoid cyst.
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