Objectives: There is no any published chronic myeloid leukemia epidemiology and evaluation of the hematological and molecular response of chronic myeloid leukemia patients. Material and Methods: This is a descriptive study conducted at National Oncology Center-Aden, South Yemen from September 2014-March 2016. Results: 50 patients were studied, 22 of them were males and 28 were females, the age is ranged between 20-71 years old with a mean age 41.9 years. The most common complaint was fatigability 86%, followed by fever and abdominal distension 78%, 76% respectively while in 82% of patients splenomegaly was the prominent sign detected during the examination. Most patients were anemic at diagnosis with a mean hemoglobin 10.2 g/ dl, leukocytosis was observed in 90% of patients ranging from 4.6 × 10 9 up to 290 × 10 9 with a mean WBC count about 40.0 × 10 9. The dramatic hematological improvement was observed with the achievement of CHR in 84% of patients which considered as an optimal response. Monitoring early molecular response after three months of starting imatinib revealed an achievement of optimal response in 60% of patients (≥ 1 log reduction of standardized baseline value which is 72.2% in our study), suboptimal or warning response is observed in 22%, (<1 log reduction but >standardized baseline value), and failure to response in 18% (6% didn't show any molecular response but still in chronic phase, 8% progress to blast crisis, 4% drug intolerance). Conclusions: 1) Chronic myeloid leukemia found to be more common in patients within 4 th-5 th decades in our study, with slight female predominance (0.8:1 M:F ratio). 2) Early molecular response is significant and optimal early molecular response was achieved by 60% of patients, 22% showed a suboptimal response while only 18% failed to show any molecular response.
Case description: A 67 years old man presented to the clinic complaining of an itchy blistering skin rash over elbows, knees and buttocks for the past 2 months that is not responding to antihistamines. Itching has no diurnal variation. Patient has no chronic comorbidities a nd is not on regular medications. On examination, symmetrical vesicular lesions with erythema, crusting and itch marks are seen over both elbows, knees and back with -ve Nicolsky's sign. General examination reveals pallor, patient BMI 17.5, abdominal diste ntion, and peripheral neuropathy. Investigations showed microcytic hypochromic anemia with HGB 9.8 mg/dl, MCV 68, HCT 29.8, WBCs and platelets are normal. K 3.1 mg/dl, Na 135 meq/dl , Ca 8.5mg/dl, albumin 3 g/dl. Skin biopsy and direct immunofluorescence of t he skin around the lesions was taken that was diagnosed as dermatitis herpetiformis. Endoscopy was done and it confirmed the diagnosis of celiac disease.Treatment: Patient was advised to follow a gluten free diet plan and dapsone was started at a dose of 1 00 mg/day. Patient rash resolved gradually over a period of 3 weeks.
Background Diabetes mellitus is a group of diseases characterized by metabolic disturbances with increasing prevalence worldwide. Individuals with diabetes mellitus present with several micro- and macro vascular complications such as retinopathy, nephropathy, neuropathy, atherosclerosis and cardiovascular disease. A higher body mass index (BMI) raises the risk of having uncontrolled diabetes and complications related to it, such as heart disease, stroke, kidney failure, nervous system and eye problems. However, recent studies have reported that being overweight may confer a protective effect against all-cause mortality and on the life expectancy of diabetic patients; this has been termed the obesity paradox. The aim to explore the association between BMI and diabetic complications among elderly patients with type 2 diabetes. Methods A case-control study was conducted on 60 elderly diabetic males and females aged ≥ 60 years recruited from the inpatient wards and outpatient clinics of Mansoura university hospitals. The sample was divided into 3groups: the first group was comprised of 26 elderly diabetic patients with normal BMI. The second group was comprised of 24 overweight elderly diabetic. The third group was comprised of 10 obese elderly diabetic. Full history taking, clinical examination, BMI measurement (kg/m2) were obtained from all participants. Results The current study showed that there was insignificant differences regarding BMI between the study groups. Hyperglycemic and hypoglycemic coma were least frequent among obese cases, while neuropathy was more frequent among cases with normal BMI. But neither of these relationships was statistically significant Conclusions: Any increase in BMI above normal weight levels was not associated with an increased risk of having complications of diabetes mellitus.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.