Summary Intrinsic skin aging is skin aging affected by natural factors within the body, such as hormones, rather than by external factors like UV light or smoking. Skin ageing causes the appearance of wrinkles, skin sagging and reduced elasticity. Like elsewhere in the body, skin ageing involves an increase in the proportion of cells undergoing cellular senescence (a type of deterioration due to age). Senescent skin cells called dermal fibroblasts have several characteristics that are different to cells that are not senescent, including having what is known as a senescence‐associated secretory phenotype (SASP). Oxytocin (OT) is a neuropeptide hormone that has many beneficial effects in the body, including protection against age‐related disorders. However, less is known about the role of OT in intrinsic skin aging. The authors looked into the role of oxytocin in prevention against senescence in skin cells called normal human dermal fibroblasts (NHDFs), taken from female donors of different ages. They found that OT suppressed SASP‐induced senescence in NHDFs derived from young but not old female donors. The authors were also able to learn more about the processes within the body by which OT suppresses SASP and why it affects younger women differently to older women. Their results demonstrate that oxytocin may be effective in the prevention of skin aging.

Summary 皮肤自然衰老是受体内自然因素(如激素)影响,而非受外部因素(如紫外线或吸烟)影响的皮肤衰老。皮肤衰老导致皱纹、皮肤下垂和弹性下降等表现。如同身体的其他部位,皮肤衰老涉及发生细胞老化(一种因为衰老导致的退化)的细胞比例增多。称为皮肤纤维母细胞的老化皮肤细胞有若干不同于未老化细胞的特征,包括具有所谓的衰老相关分泌表型 (SASP)。 催产素 (OT) 是一种神经肽,对身体有很多有益作用,包括防止衰老相关疾病。但是,关于 OT 在皮肤自然衰老中的作用所知不多。 作者们调查了催产素在防止来自不同年龄女性供体的称为正常人真皮纤维母细胞 (NHDF) 的皮肤细胞衰老中的作用。他们发现,OT 抑制了来自年轻而非年老女性供体的 NHDF 中 SASP 引发的衰老。 作者们还得以了解到更多有关 OT 抑制 SASP 的体内过程以及为何它对年轻和年老女性的影响不同的信息。他们的结果显示,催产素可能对防止皮肤衰老有效。