The power of association studies between polymorphic genetic variants and breast cancer may be enhanced if the cancer subjects are subclassified by histologic subgroup. In this study we classified 482 unselected breast cancers from Szczecin, Poland by histology (ductal, lobular, medullary, other). All women were genotyped for three founder mutations in the CHEK2 gene (1100delC, IVS2 + 1G > A and I157T). There was no significant overall association between CHEK2 and breast cancer (OR = 1.3; p = 0.30), but among those with lobular carcinoma the association with the I157T missense mutation was very strong (OR = 6.6; p > 0.0001). This is the first report to demonstrate that different mutations of the same gene may be associated with specific histologic subtypes of cancer.
Electron microscopic studies of human tumors having the structure of fibromatosis hyalinica are reported. the chief fine structural findings were the balls filled with delicate fibrils surrounding the Golgi zone in the tumor cells, and the presence of a peculiar kind of delicate fibril in their stroma. It was supposed that this type of hitherto undescribed change in the Golgi zone was connected in some way with the overwhelming production of the stroma microfibrils.
An ultrastructural study of a postirradiation pseudosarcoma of the skin is reported and compared to the spindle cell variant of squamous carcinoma in order to exclude epithelial histogenesis of the former. The pseudosarcoma tissue was composed of cells having the ultrastructural features characteristic of myofibroblasts. The cells of the spindle cell variant of the squamous carcinoma demonstrated the presence of tonofibrils which were joined by many desmosomes. These findings contradict the concept of an epithelial origin of the spindle‐shaped cells of pseudosarcoma.
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