Bone marrow stimulation techniques such as microfracture for the treatment of articular cartilage defects so far solely reproduce mechanically inferior fibrous cartilage tissue, which might result in unsatisfactory clinical results at midterm. The combination of microfracture and biomaterialsdfor example, autologous matrix-induced chondrogenesis technologydhas not yet proved that the disadvantages of the marrow stimulation techniques can be overcome. At present, only laboratory-cultivated autologous chondrocytes are able to restore a biomechanically superior cartilage layer and might lead to superior functional results. However, the costs are high and the patient must undergo a 2-stage procedure. By selecting the appropriate cell fraction in conjunction with a controlled release of differentiating growth factors, sufficient cartilage regeneration might be achievable on the basis of bone marrow aspirate as well. We thus describe an advanced surgical technique for the treatment of articular cartilage defects based on platelet-rich plasma and bone marrow aspirate concentrate to overcome these drawbacks.
Knorpelregenerative Therapieverfahren sind in den letzten Jahren feste Bestandteile der orthop?disch-traumatologischen Behandlung geworden. F?r die Therapie ist es erforderlich, die Sch?digung sowohl als mechanisches, aber auch als biochemisches Problem zu erkennen.
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