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The studied non-contact screening device detects accurately the combination of the sleep disorders SDB and/or PLM. However, further testing is required in order to specify the nature of the underlying sleep disorder. At the current stage of algorithm development, the clinical strength is that the studied non-contact device can be used as a rule-out screening device for SDB and PLM.

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reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide.

The inhibition of bone metabolism and development of osteoporosis under treatment with unfractionated heparins (UFH) have been discussed, whereas the pathomechanism and the question of whether low-molecular-weight heparins (LMWH) have an influence on bone healing as well remain unclear. In a blinded trial, three groups of ten rabbits received subcutaneous injections of an unfractionated heparin (sodium heparin), a low-molecular-weight heparin (certoparin), or normal saline over a period of 6 weeks after a standardized bone defect had been applied to both femur condyles. Healing of the defects was investigated in a depth of 1 and 2 mm and the remaining volume of the bone defects was measured. After therapy with UFH, the volume of the defects remained significantly larger in a depth of 1 mm (UFH/control: p<0.001; UFH/LMWH: p<0.005) and in the total depth (UFH/control: p<0.005; UFH/LMWH: p<0.025). After therapy with LMWH, there was no inhibition of defect healing (p>0.05). This study shows that the influence of heparins on fracture healing can be reduced significantly by using LMWH instead of UFH.

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