Significance and Impact of the Study: Methicillin-resistant Staphylococcus aureus is the pathogen represents a considerable burden on the healthcare system worldwide, and resistance to nearly all β-lactam antibiotics. For the first time, we evaluated the antibacterial activity and the synergy of the sanguisorbigenin (SGB) combined with β-lactam antibiotics against methicillin-resistant S. aureus. The result indicated that SGB has a potent antibacterial effect and could effectively reverse the sense of β-lactam antibiotics by inhibiting mecA expression and decrease the PBP2a expression. This study has a certain reference value for the development of novel antibacterial agents and antibiotic modulators.
Luo et al.: Drug resistance pathogens in patients with urinary calculi Main objective is to explore the characteristics, drug resistance, and risk factors of pathogens in urinary tract infection patients complicated with urinary calculi. A total of 417 patients with urinary calculi who were treated in our hospital from January 2017 to December 2019 were enrolled in this study, including 234 patients with urinary tract infection and 183 patients without urinary tract infection. The midstream urine of 234 patients with urinary tract infection were cultured and used in the drug sensitivity test. Univariate and multivariate logistic regression analysis was used to analyze the risk factors of postoperative urinary tract infection in patients with urinary calculi. A total of 624 strains of pathogens were isolated from the urine samples of 234 patients with postoperative urinary tract infection, of which 386 strains were gram-negative bacteria (61.86 %), 169 strains were gram-positive bacteria (27.08 %), and 69 strains were fungus (11.06 %). In the drug resistance test, the resistance rates of Staphylococcus aureus to tetracycline, rifampicin, and levofloxacin, and the resistance rate of Enterococcus faecium to levofloxacin was low. Enterococcus faecalis had the lowest resistance rate to levofloxacin, followed by azithromycin and gentamicin. The resistance rates of Staphylococcus epidermidis to levofloxacin and vancomycin were low and the resistance rate to erythromycin was 100.00 %. The resistance rate of Acinetobacter baumannii, Escherichia coli, Pseudomonas aeruginosa, and Proteus mirabilis to meropenem and amikacin, and the resistance rate of Klebsiella pneumoniae and Proteus mirabilis to etilmicin and ceftriaxone were low.
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