Drug-induced photosensitivity refers to the development of cutaneous disease as a result of combined effects of a chemical and light. Photosensitivity reactions may result from systemic medications and topically applied compounds. Pirfenidone is known to cause photosensitivity reactions, rash, pruritus and dry skin at high doses. However, similar adverse reactions with low doses of Pirfenidone have not been reported. We report a case of photosensitivity reaction induced by low-dose Pirfenidone in a patient with idiopathic pulmonary fibrosis (IPF).
ABSTRACT:To compare effectiveness of intravenous iron-sucrose versus oral ferrous sulphate in pospartum anemia in rural area. METHODS AND MATERIAL: In this study, 120 women with postpartum anemia with hemoglobin (Hb) less than 10 g/dl within 48 h postpartum were randomised into two groups. Group I consisted of 60 women who received 300-600 mg of intravenous iron-sucrose every alternate day for 3 days. Group II consisted of 60 women who were given 300 mg ferrous sulphate orally daily for a month. Data collected after 1 month for Hb estimation and other postpartum parameters are assessed. RESULTS: The mean Hb was significantly increased in the intravenous iron sucrose group in 4th week of treatment but there was minimal change observed in mean Hb in patients treated with oral ferrous sulphate. Women treated with intravenous iron sucrose has shown significantly higher Hb as compared to those treated with oral iron. CONCLUSIONS: Overall intravenous iron sucrose appears to be an effective and safe mode of treatment in postpartum patients with no serious side effects than oral iron therapy.
Background: Superficial mycoses are common worldwide. Dermatophytic infections can greatly affect quality of life. Several newer antimycotic agents, have been reported effective and safe. Hence this study was planned to analyse effectiveness as well as cost effectiveness of these treatments.Methods: It were a prospective, randomized, parallel, open label, comparative study. Fifty patients were included in the study and divided into 2 groups. They were randomized to receive either oral terbinafine 250 mg or itraconazole 100 mg once daily for 4 weeks. Scaling, erythema and pruritus were rated as clinical score 0 to 3: 0 - absent, 1 - mild, 2 - moderate, and 3 - severe for the above three target symptoms. Total symptom score was assessed. Pruritus was also graded on visual analogue scale (VAS). Mycological cure was assessed by skin scraping with KOH mounts and fungal culture. Clinical efficacy scoring and VAS were assessed before the study and at each follow up visit at 2 and 4 weeks. Patients were followed up for another 4 weeks after completion of the treatment.Results: There was highly significant decrease p<000.1 in the mean total symptoms scores in both the study groups from baseline. No significant difference in the mean total symptoms score was observed when compared between groups. ADRs were more in terbinafine group.Conclusions: Both terbinafine and itraconazole are effective and safe against superficial mycoses, but adverse effects are more with terbinafine. Itraconazole was found to be cost effective compared to terbinafine.
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