No abstract

The scientific literature presents quite a large number of works, in which the priority role of mathematical modeling in providing high-quality medical care, health and active longevity of a person is determined. The purpose of the work is to construct and analyze the regression models of individual sonographic sizes of kidneys in practically healthy women of the middle intermediate somatotype, depending on the features of the anthropometric and somatotypological indicators. Within the framework of the agreement on scientific cooperation from the database of National Pirogov Memorial Medical University, Vinnytsya primary sonographic parameters (length, width, anterior-posterior dimension, area of longitudinal and cross-section of the kidneys and their sinuses, as well as volume of the right and left kidneys) and anthropometric indices (obtained by the method of V.V. Bunak in the modification of P.P. Shaparenko) of 17 practically healthy women of the first mature age of the middle intermediate somatotype, who in the third generation live in the Podillya region of Ukraine. The construction of regression models of individual sonographic sizes of the kidneys, depending on the features of anthropo-somatotypological parameters of the body of women of the middle intermediate somatotype, was carried out in the licensed package “Statistica 6.1”. In women of the middle intermediate somatotype all 16 possible reliable regression models of sonographic parameters of the kidneys were constructed depending on the anthropo-somatotypological parameters with the determination coefficient R2 from 0.891 to 0.978. The analysis of reliable regression models (with a coefficient of determination greater than 0.6), the sonographic parameters of the kidneys in practically healthy women of the middle intermediate somatotype revealed that most often models of both kidneys, as well as separately of the right and left kidneys, include the circumferential dimensions of the body (respectively, 35.9 – 33.3 – 38.5% of the total number of indicators included in the models). In addition, models of both kidneys most often include cephalometric indices (12.6%), thickness of skin-fat folds and body diameters (by 11.7%); models of the right kidney – body diameters (15.7%), cephalometric indices and width of distal epiphyses of long tubular bones of extremities (by 11.8%); models of the right kidney - the thickness of skin and fat folds (17.3%) and cephalometric indices (13.5%). Attention is drawn to the lack of entry into models of sonographic sizes of kidneys total body sizes.

Given the most frequent manifestation of psoriasis at a young working age and in some cases severe, continuously recurrent course, the presence of many treatments, none of which is a guarantee of complete recovery and no recurrence – now there is an urgent need to find prognostic signs therapy and prevention of relapses. In the absence of ideal biomarkers, the study of constitutional markers becomes crucial. The aim of the study was to examine the differences in girth body sizes between healthy and/or psoriatic men depending on the severity of the disease. Anthropometric examination according to V.V. Bunak was performed for 32 men of the first mature age patients with mild and 68 with severe psoriasis course. The PASI index was used to clinically assess the severity and area of psoriatic lesions. The control group, according to anthropometric parameters, consisted of 82 practically healthy men of the same age, selected from the database of the research center of National Pirogov Memorial Medical University, Vinnytsya. Statistical data processing was performed in the license package “Statistica 5.5” using non-parametric methods of evaluation of the obtained results. In patients with psoriasis of mild and severe course, compared with healthy, we found: greater values for – the girth of the shoulder in a tense state by 8.9% and 6.8%; shoulder girth in the unstressed state by 14.2% and 12.3%; forearm girth in the upper part by 8.0% and 7.1%; forearm girth in the lower part by 4.2% and 4.5%; hand girth by 5.1% and 5.8%; hip girth by 11.4% and 9.3%; hips circumference by 8.7% and 6.5%; crus girth in the upper part by 10.2% and 7.9%; crus girth in the lower part by 8.7% and 5.9%; neck girth by 6.9% and 7.8%; waist circumference by 17.1% and 18.2%; chest girth on inspiration by 7.8% and 7.2%; chest girth on exhalation by 10.6% and 10.3%; chest circumference at rest by 10.0% and 9.6%. Thus, there are pronounced differences in the girth sizes between healthy and patients with mild and severe psoriasis Ukrainian men of the first mature age. Between patients with varying degrees of severity of dermatosis, differences are established only for the girth of the crus in the lower part.

In this work, we undertook a study of the sonographic parameters of the pancreas and gall bladder in healthy men with different somatotypes. The study-subjects were from the Podillya region of Ukraine. Herein, the majority of gallbladder dimensions (length, thickness, cross-sectional area and volume) in men type-classified as endo-mesomorphic, were significantly higher when compared with men in general and with those of the meso- and ecto-mesomorphic somatotype. Furthermore, the dimensions of the pancreas (width of head and tail length) in mesomorphic males were significantly higher than that of endo-mesomorphic males. The rest of the studied parameters (length, longitudinal cross section area of the gall bladder, the thickness of the head, body and head length, the width of the body and tail of the pancreas) in men of the different somatotypes have no significant differences.

ПЕРЕДОВАЯ СТАТЬЯ КЛИНИКА И ФАРМАКОТЕРАПИЯХирургическая реваскуляризация миокарда путем такой операции, как аортокоронарное шунтирование (АКШ), на настоящий момент является наиболее эффективным способом лечения ишемической болезни сердца (ИБС), снижающим риск развития сосудистых осложнений [1]. Вместе с тем, давно известно, что у пациентов с сердечно-сосудистыми заболеваниями (ССЗ) после операции коронарного Цель. Изучить состояние мозгового кровотока и когнитивные функции у паци-ентов с ишемической болезнью сердца (ИБС), перенесших коронарное шунти-рование (КШ) в условиях искусственного кровообращения (ИК), и оценить влияние цитиколина на состояние высших мозговых функций в ранний и более поздний периоды после перенесенного оперативного вмешательства. Материал и методы. На базе Федерального центра сердечно-сосудистой хирургии (г. Красноярск) обследовано 66 пациентов с диагнозом ИБС муж-ского и женского пола. Пациенты были разделены на две группы. В основной группе (n=36) в качестве средства церебральной нейропротекции использо-вали препарат цитиколин (Цераксон): внутривенно за сутки до операции, в дозе 1000 мг, растворенный в 200 мл 0,9% NaCl, затем в течение 7 суток после операции с последующим приемом препарата в дозе 900 мг/сут. внутрь в течение 2 месяцев. В группе сравнения (n=30) в периоперационном периоде нейропротекция не проводилась. Результаты. К 12-му месяцу после оперативного вмешательства удалось вернуть показатели когнитивных функций к исходным значениям. В контроль-ной группе через 12 месяцев после операции КШ когнитивные функции верну-лись к дооперационному уровню лишь по тесту зрительное запоминание 5 слов (непосредственное воспроизведение). Заключение. Нейропротективная терапия цитиколином может рассматри-ваться как метод, позволяющий улучшить состояние когнитивных функций пациента после таких повреждающих воздействий, как операция с примене-нием ИК, и, тем самым, достичь наиболее высокого уровня повседневного функционирования пациентов после КШ. Aim. To assess the condition of cerebral circulation and cognitive functions in patients with coronary heart disease (CHD), underwent coronary bypass (CBG) operation under on-pump conditions and to evaluate the influence of citicoline on the higher brain functions at earlier and delayed periods post-surgery. material and methods. In the Federal center of cardiosurgery (Krasnoyarsk city) 66 patients studied, with diagnosis CHD. Patients selected to 2 groups. Main group (n=36) as a medium for cerebral neuroprotection we used citicoline (Ceraxon): intravenous, 1 day before surgery, 1000 mg on 200 mL of saline, and then for 7 days after surgery, with further intake of the drug 900 mg/daily for 2 months. In comparison group (n=30) there was no neuroprotection in peri-operation period.Results. By the 12th month after surgery, cognition returned to baseline values. In controls, by 12 months after CBG, cognition returned to baseline only by the test "visual memory" of 5 words (direct remembering). Conclusion.Neuroprotection by citicoline might be a method for ...

Eczema is a skin disease with a multifaceted clinical picture, numerous forms of manifestation and course and, last but not least, a life-modifying pathology that often requires lifestyle changes and reduces its quality. Identifying prognostic signs to predict the occurrence and severity of this disease is a priority for modern science. The purpose of the study is to build and analyze discriminant models of the possibility of occurrence and features of course of different forms of eczema in Ukrainian men of the first mature age depending on the characteristics of anthropometric parameters of the body. For men aged 22 to 35 years with true (n=34, including 16 mild and 18 severe) and microbial (n=38, including 28 mild and 10 severe) eczema, anthropometric examination according to the scheme of Bunak V.V. performed. Diagnosis of eczema was performed according to the nomenclature of ICD-10. The control group according to anthropometric data consisted of 82 practically healthy men of the same age, who were selected from the database of the research center of National Pirogov Memorial Medical University, Vinnytsya. Construction of discriminant models of the possibility of occurrence and features of the course of different forms of eczema depending on the anthropometric parameters of the body was carried out in the license package “Statistica 5.5”. It was found that the distribution of sick men on the truth of mild and severe eczema and microbial eczema of mild and severe course is possible only reliable interpretation of the obtained classification indicators between healthy and groups of patients (correct function in 76.0 % of cases, statistics Wilks’ Lambda = 0.074); when dividing sick men only into truth and microbial eczema – a reliable interpretation of the obtained classification indicators both between healthy and sick, and between sick truth and microbial eczema is possible (function is correct in 87.7 % of cases, Wilks’ Lambda statistics = 0.088); in the distribution of sick men only for mild or severe eczema – possible reliable interpretation of the obtained classification indicators between healthy and sick men, and between patients with mild or severe eczema only a slight tendency to interpret the obtained classification indicators (correct function in 84.4 % of cases, statistics Wilks’ Lambda = 0.088). In all cases, the constructed discriminant equations most often include the thickness of skin and fat folds (62.5 %, 57.1 % and 71.4 %, respectively) and body diameters (37.5 %, 42.9 % and 28.6 %, respectively). The obtained results confirm the prospects of using anthropometric research methods to predict the possibilities and features of eczema course and occurrence.

Adrenaline damage to the myocardium is an important element in the pathogenesis of myocardial infarction in humans. Despite the use of modern methods of treatment of myocardial infarction, the issue of cardioprotection of reperfusion myocardial damage remains open. Promising in this direction is the use of quinazolone derivatives, which have already shown cardioprotective properties in other models of myocardial infarction. The aim of the study was to establish morphological changes in the conditions of adrenaline myocardiodystrophy (AMD) against the background of the introduction of the compound PC-66 and amiodarone in rats. The study was performed on 100 nonlinear rats of both sexes weighing 165-220 g, divided into four groups of 25 animals each: 1 – intact rats; 2 – rats with a model of adrenaline myocardial infarction without treatment (control); 3 – rats with AMD treated with amiodarone (10 mg/kg, intraperitoneally); 4 – rats with AMD treated with compound PC-66 (10 mg/kg, intraperitoneally). It was found that control rats under conditions of cardiotoxic dose of adrenaline in the left ventricular myocardium for up to 8 days of the experiment does not fully restore the myocardial structure, dystrophic and necrobiotic changes were found in both cardiomyocytes and walls of vessels of a blood microcirculatory channel of a myocardium. Course intraperitoneal administration to rats of the compound PC-66 in the conditions of adrenaline myocardial infarction as well as amiodarone, contributes to the attenuation of signs of dystrophic and destructive processes. The degree of protective effect on the myocardium under conditions of cardiotoxic dose of adrenaline compound PC-66 was not lower to the reference drug – amiodarone. Thus, it is morphologically confirmed that in adrenaline myocardial infarction the compound PC-66, similar to the action of amiodarone, has a cardioprotective effect.

Additional factors of the shot are one of the key pieces of physical evidence that are investigated in the case of a gunshot injury in order to establish the distance and identify the weapon of the shot, as evidenced by the results of numerous scientific works. However, publications related to the study of non-lethal firearms are isolated cases and incomplete both in the world and in the domestic scientific literature. The purpose of the work is to investigate the deposition of additional factors of the shot on different cover materials and bare blocks, which are imitating the tissues of the human body at different shot distances, using «Fort 9R» and «Fort 17R» pistols. Material and methods. In order to achieve the goal, 120 gelatin blocks covered with different fabrics or left without a coating were fired. The shooting was carried out using «Fort 9R» and «Fort 17R» pistols. The fired blocks were examined for the presence of soot using a descriptive method and microscopic examination, and subsequently using a chromatographic-mass spectrometric method of examination and infrared microscopy on a combined IR-Fourier spectrometer in order to detect diphenylamine and centralite. Results. When shooting from «Fort 9R» and «Fort 17R», the deposition of soot was observed at a distance of a shot at close range and 25 cm on all studied blocks, and also  when shooting from «Fort 17R» on blocks covered with cotton fabric and in bare blocks, soot was detected microscopically on shot distance 50 cm; diphenylamine and centralite was observed when firing from «Fort 9R» in bare blocks (close and 25 cm) and blocks covered with leatherette (25 cm), while when firing from «Fort 17R» it was detected only at a shot distance of 25 cm on blocks covered with denim fabric. Conclusions. The presence of clothing and the peculiarities of the material of its manufacture fundamentally change the macro, microscopic and laboratory picture of the deposition of additional factors of the shot at different distances, using the «Fort 9R» and «Fort 17R» pistols, with the exception of the soot deposition when firing from the «Fort 9R» pistol.