The importance of the tumor microenvironment in cancer progression has been well studied for many years. Immune checkpoint inhibitors (ICIs) are regarded as potential strategies in enhancing the immune responses in patients with cancer, particularly colorectal cancer (CRC). Notably, CRCs are extraordinarily heterogeneous and mostly are microsatellite‐stable (MSS) or cold tumors, which means that the immune response is not usually as strong as that of foreign cells. T‐cell immunoglobulin and ITIM domain (TIGIT) is a new immune checkpoint receptor overexpressed inside the CRC tumor‐immune microenvironments. Moreover, several studies have shown that TIGIT in combination with other ICIs and/or conventional treatments, can lead to a robust anti‐tumor response in CRC. This review looks deep inside TIGIT expression patterns, their various functions, and possible immunotherapy strategies to increase survival rates and decrease immune‐related adverse events.
The process of introducing information technologies into the activities of St. Petersburg enterprises and organizations is considered. The level of use of digital capabilities in enterprises is assessed, the areas of production activity where their use is most effective are analyzed. The data of a survey of urban enterprises conducted in preparation for a special meeting of the Presidium of the Union of Industrialists and Entrepreneurs of St. Petersburg are presented. The level of computer literacy of employees, the state of the knowledge acquisition system in the field of digitalization, the role of enterprises in organizing the process of appropriate professional training and in the application of digital technologies are discussed.
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