INTRODUСTION Unfavorable ecology, demographic situation in Ukraine, somatic and oncologic diseases frequency increase, immunity and living standard decrease have predetermined the increase of number of women with endometrial hyperproliferative processes who stand for 5-20% obstetric-gynecologic profile, according to the statistical data [2, 6, 14, 16, 19]. Nowadays regardless of the scientific achievements, diagnostics, surgery and curative methods improvement, the problem of intrauterine pathology treatment still remains topical in the medical and social aspects which is determined by the high risks of neoplastic transformation and steady tendency towards the recurrence frequency increase (proportional transformation into atypia), which according to the homeland and foreign authors stands for 26 to 78% among women [1, 3, 15, 17-19, 22]. High recurrence frequency serves the ground for the repeated surgical operations [10, 12, 18, 21, 23], and sometimes they are not limited with traditional approaches possibilities, that is increases the topicality study of the main aspects of disease. Relevance of the problem is determined by the probability of the endometrial hyperplastic processes transformation into the endometrial cancer. Numerous researches prove the probability of the oncological processes development with the background of endometrial polyposis from 4% up to 67.2% of patients [13, 24, 25]. The endometrium polyposis treatment methods are standard ones and foresee the polyp's ablation followed by the hormonal therapy, nevertheless the recurrence value remains rather high standing for 25.9% to 78% [4, 5, 11]. The disease's etiopathogenesis complexity, different trends in its stages' interpretation, tactical approaches ambiguity (with and without considering the hormonal disorder individual specific features) constitute definite difficulties while choosing the pathogenetically treatment. These are the circumstances to determine the increased scientific and practical interest in the endometrial polyposis treatment and management [7, 8, 9, 22]. The topicality of our research has been determined by the controversial point of view on the uterus polyps pathogenesis, high recurrence frequency after hormonal therapy, immune system dysfunction and inflammation role in the endometrial polyposis genesis. The purpose of research: to increase the treatment effectiveness of patients with endometrium local hyperplasia (endometrium polyposis) by applying of the new endoscopic technologies and pathogenetically substantiated post-surgery therapy. MATERIALS AND METHODS 66 women aged 24-43 years participated in the research. The treatment algorithm consisted of four stages in accordance with Order of the Ministry of Health or Ukraine No. 676 dated by 31.12.2004. Stage І-hysteroscopic mutated endometrial and polyp ablation followed by the morphological research and the following determination of tactics depending on the pathology type along with the complex anti-inflammatory, anti-bacterial and anti-viral treatment. Stage II-horm...
Cholestatic hepatosis of pregnant women complicates approximately 0.2% to 2% of pregnancies and may increase the risk of pregnancy and fetal pathology. The article provides information on diagnosis, treatment methods and possible risks to pregnant women and the fetus associated with cholestatic hepatosis of pregnancy. The diagnosis of cholestatic hepatosis of pregnant women is usually based on clinical (itching) and laboratory (elevated bile acid levels) signs. Other markers that reflect liver function, such as alanine aminotransferase and aspartate aminotransferase, are also often elevated, and this requires a differential diagnosis with other pathological conditions leading to liver dysfunction. Cholestatic hepatosis of pregnant women causes an increased risk of premature birth, fetal distress, respiratory distress syndrome of the newborn and stillbirth. There is evidence that with increasing levels of bile acids increases the risk of adverse effects for newborns. Ursodeoxycholic acid therapy reduces maternal symptoms, but this therapy has not been shown to reduce risks to the fetus. Women diagnosed with cholestatic hepatosis in pregnant women have a high risk of recurrence during subsequent pregnancies and hepatobiliary disease later in life. Keywords: cholestatic hepatosis of pregnant women, intrahepatic cholestasis of pregnant women, obstetric cholestasis.
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