A 13‐year‐old boy and his sisters (11 and 14, respectively] consulted us for the same derniatoses. The boy and the elder sister had been suffering for over 4 years, while the younger sister was in her first year of the disease. The clinical pictures were alike: many circular or oval patches of furfuraceous desquamation scattered over the trunk and limbs. Lesions were sharply demarcated and frequently confluent with a polycyclic outline (Figs. 1, 2). Their size varied from 2–3 cm to more than 10 cm and they numbered more than 40 in every patient. The patches were hypochromic and prominent over the sunbathed skin (Fig. 1); the boy alone bad a few lesions darker than the surrounding skin. The dermnloses appeared to fluctuate in severity with a modest improvement during summer, While its extension remained unchanged, a follow up after a year revealed that single lesions had eilber disappeared or spread out while new ones had surfaced; furthermore, the boy had no more hyperchromic lesions. The skin elsewhere was normal. We examined the parents and were surprised to learn that their father suffered from ichtbyosis vulgaris (IV) (Fig. 3); in addition, he stated that his mother had the same disease; he could not specify if other members of the family had any signs of IV or PR. Microscopic examinations and cultures were carried out in the children and were repeatedly negative for fungi. A bistologic examination was obtained from the father and his son. Both IV and PR sbowed the same picture: a moderate byperkeratosis (strictly ortokeratotic) surmounted an absent or reduced granular layer and an otherwise normal epidermis.

A case of infantile acropustulosis is described. The condition responded to sulfones while it was not affected by any other therapy. Histologically, subcorneal pustules were found; persistent modest eosinophilia and eosinophils were present in the vesicular content, a feature never observed before. The significance of this finding is discussed.