Dependent on their cell concentrations, M. species have the ability to generate ROS. The ability of the different Malassezia species to produce ROS should be considered as one further virulence factor of this yeast. The antifungal agent terbinafine (concentrations from 100 microg to 1 microg ml -1) reduced ROS production by M. furfur and M. pachydermatis. Terbinafine acts as oxygen species scavenger. This could be an additional mechanism supporting the classic antifungal effect of this agent, the inhibition of ergosterol synthesis.
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