CUPID-Mo is a bolometric experiment to search for neutrinoless double-beta decay (0νβ β ) of 100 Mo. In this article, we detail the CUPID-Mo detector concept, assema e-mail: andrea.giuliani@csnsm.in2p3.fr bly, installation in the underground laboratory in Modane in 2018, and provide results from the first datasets. The demonstrator consists of an array of 20 scintillating bolometers comprised of 100 Mo-enriched 0.2 kg Li 2 MoO 4 crystals. The

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The treatment of deep-seated tumours with electrons of very high energies (VHEE, 70–150 MeV) has already been explored in the past, suggesting that a dosimetric coverage comparable with state-of-the-art proton (PT) or photon radiotherapy (RT) could be achieved with a large (> 10) number of fields and high electron energy. The technical and economical challenges posed by the deployment of such beams in treatment centres, together with the expected small therapeutic gain, prevented the development of such technique. This scenario could radically change in the light of recent developments that occurred in the compact, high-gradient, electron acceleration technology and, additionally, of the experimental evidence of the sparing of organs at risk achieved in ultra-high dose rate irradiation, also referred to as FLASH. Electrons with the energy required to treat intracranial lesions could be provided, at dose rates compatible with what is needed to trigger the FLASH effect, by accelerators that are a few metres long, and the organ sparing could be exploited to significantly simplify the irradiation geometry, decreasing the number of fields needed to treat a patient. In this paper, the case of two patients affected by a chordoma and a meningioma, respectively, treated with protons in Trento (IT) is presented. The proton plans have been compared with VHEE plans and X-ray intensity-modulated radiotherapy (IMRT) plans. The VHEE plans were first evaluated in terms of physical dose distribution and then assuming that the FLASH regimen can be achieved. VHEE beams demonstrated their potential in obtaining plans that have comparable tumour coverage and organs at risk sparing when benchmarked against current state-of-the-art IMRT and PT. These results were obtained with a number of explored fields that was in the range between 3 and 7, consistent with what is routinely performed in IMRT and PT conventional irradiations. The FLASH regimen, in all cases, showed its potential in reducing damage to the organs placed nearby the target volume, allowing, particularly in the chordoma case where the irradiation geometry is more challenging, a better tumour coverage with respect to the conventional treatments.

γ-ray spectrometry is a well-known technique in environmental radioactivity measurements where easily handled systems are needed. Scintillators coupled to a photomultiplier tube (PMT), are typically favoured over solid-state detectors as mobile spectrometers. Replacing PMT with position sensitive devices represents an innovative solution that provides the evaluation of the interaction point of the incident radiation. The knowledge of spectrometry as a function of the depth of interaction (DoI) assures a better understanding of the spectrum and a more reliable identification of the source. In this paper, the efficiency of a simple DoI estimator has been studied using a CRY018 monolithic crystal coupled to a multi-anode photomultiplier tube. The DoI estimator has been evaluated studying charge distributions and the dependency of spectrometric properties on the DoI has been qualitatively analyzed. The estimator has shown to be highly sensitive to the DoI, enabling a better understanding of the internal interaction processes of light and an efficient rejection of the background component on the spectra. The novelty of this work lies in the application of the DoI selection in spectrometry made available by the use of MAPMT. The proposed method is practical since it does not require complicated hardware solutions or complex computational procedures.